Dnmt3L and the Establishment of Maternal Genomic Imprints

By D. Bourc’his, Guo-Liang Xu, Chyuan-Sheng Lin, Brooke Bollman, T. Bestor. Science, 2001

1,423 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/cd729f06b5f3d73cdbbef2a5cea2433231f5a5d0

How researchers see this paper

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In Genetics

1. A. Bird
2. Manel Esteller
3. E. Li
4. Anne Ferguson-Smith
5. Felix Krueger
6. Simon R. Andrews
7. R. Jaenisch
8. Keith D. Robertson

In Molecular Biology

1. Yi Zhang
2. A. Bird
3. Manel Esteller
4. Hao Wu
5. E. Li
6. Keith D. Robertson
7. Felix Krueger
8. Dirk Schübeler

In Pediatrics, Perinatology and Child Health

1. Anne Ferguson-Smith
2. Hiroyuki Sasaki
3. R. Martienssen
4. Yasuhisa Matsui
5. E. Li
6. T. Bestor
7. A. Bird
8. Keith D. Robertson

Citations in the corpus

• DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “Dnmt3L homozygous-null mice are viable, whereas heterozygous embryos derived from homozygous Dnmt3L-null oocytes die around E9 and display impaired maternal methylation imprints and biallelic expression of imprinted genes normally expressed only from the allele of paternal origin.(18) Cooperation am”
• Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “Furthermore, targets include Dnmt3L (Figure 2C and Figure S6), a germline-specific cofactor for the de novo methyltransferases Dnmt3a and Dnmt3b, which is essential for establishing genomic imprinting marks during germ cell development (Bourc’his et al., 2001).”
• Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. (2002, background): “Bourc’his et al. (Bourc’his et al., 2001) reported that several imprinted genes on chromosome 7 were expressed from both paternal and maternal alleles and two other genes, Ip1and Cdkn1, were silent in embryos from Dnmt3L–/– mothers.”
• Transposable elements and the epigenetic regulation of the genome (2007, background): “This de novo DNA methyltransferase gene is expressed exclusively in female germ line cells and is responsible for DNA methylation and establishment of some genomic imprint”
• Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “Its regulatory factor, DNMT3L, is also required for the establishment of germline imprint”
• Linking DNA methylation and histone modification: patterns and paradigms (2009, background): “, a closely related homologue that lacks methyltransferase activit”
• Epigenetic modifications and human disease (2010, background): “The DNMT3 family contains a third member, DNMT3L, which is required for establishing maternal genomic imprinting, despite being catalytically inactiv”
• How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “Germline-specific DNA methylation was shown to be defective in mice deficient in the DNMT3-like protein (DNMT3L), a DNMT3 family member that lacks intrinsic methyltransferase activit”
• A maternal-zygotic effect gene Zfp57 maintains both maternal and paternal imprints (2008, background): “Studies in which the de novo and maintenance DNA methyltransferase machinery has been mutated have proven that germline establishment and post-fertilization maintenance of differential methylation is essential for the monoallelic activity of imprinted genes (Bourc’his et al., 2001; Kaneda et al., 20”