A maternal-zygotic effect gene Zfp57 maintains both maternal and paternal imprints

By Xiajun Li, Mitsuteru Ito, Fen Zhou, Neil A. Youngson, Xiaopan Zuo, P. Leder, Anne Ferguson-Smith. Developmental Cell, 2008

648 citations recorded by the source corpus.

Summary The mechanisms responsible for maintaining genomic methylation imprints in mouse embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding a KRAB zinc finger protein. Loss of just the zygotic function of Zfp57 causes partial neonatal lethality, while eliminating both maternal and zygotic functions of Zfp57 results in a highly penetrant embryonic lethality. In oocytes, absence of Zfp57 results in failure to establish maternal methylation imprints at the Snrpn imprinted region. Intriguingly, methylation imprints are re-acquired specifically at the maternally derived Snrpn imprinted region when the zygotic Zfp57 is present in embryos. This suggests that there may be DNA methylation-independent memory for genomic imprints. Zfp57 is also required for the post-fertilization maintenance of maternal and paternal methylation imprints at multiple imprinted domains. The effects on genomic imprinting are consistent with the maternal-zygotic lethality of Zfp57 mutants.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/04bbe6940b8642f7633cba5222d23c6e0012c131

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Wolf Reik
2. W. Dean
3. Yi Zhang
4. Jörn Walter
5. Hao Wu
6. Fátima Santos
7. Anne Ferguson-Smith
8. Felix Krueger

In Molecular Biology

1. Yi Zhang
2. Hao Wu
3. Wolf Reik
4. W. Dean
5. Jörn Walter
6. Felix Krueger
7. Fátima Santos
8. Simon R. Andrews

In Pediatrics, Perinatology and Child Health

1. Wolf Reik
2. Jörn Walter
3. Yi Zhang
4. W. Dean
5. Fátima Santos
6. Anne Ferguson-Smith
7. Hao Wu
8. E. Li

Citations in the corpus

• The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, background): “…embryos share similarities including passive and active demethylation, with perhaps a key difference being the continuing protection from demethylation of imprinted DMRs by Zfp57 in preimplantation embryos and ESCs, which is lacking in PGCs (Li et al., 2008; Quenneville et al., 2011).”
• Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “Factors important for this process have been identified, including the KRAB zinc finger protein ZFP57 (Ref”
• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “Recent evidence suggests that maintenance of 5mC at ICRs is perhaps conferred through targeting DNMT1 and/or DNMT3A to these regions by zinc finger transcription factor ZFP57 and its partner, KAP1 (also known as TRIM28) (Li et al., 2008; Messerschmidt et al., 2012; Quenneville et al., 2011).”
• KRAB zinc finger proteins (2017, background): “At imprinting control regions, where a methylated hexanucleotide is recognized in mouse and human by ZFP57, this results in the trans-generational preservation of imprinting (Quenneville et al., 2011; Li et al., 2008; Strogantsev et al., 2015).”
• DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “Are genes such as Trim28 and Zfp57 also expressed in PGCs, and do they influence the demethylation dynamics of these regions?”
• Transgenerational Epigenetic Inheritance: myths and mechanisms (2014, neutral): “Also, the DNA-binding factor Zfp57, together with Kap1/Trim28, is critical for postfertilization maintenance of maternal and paternal methylation imprints (Li et al., 2008; Messerschmidt et al., 2012).”