Interchromosomal interactions and olfactory receptor choice.

By S. Lomvardas, G. Barnea, D. Pisapia, Monica Mendelsohn, Jennifer Kirkland, R. Axel. Cell, 2006

635 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/cce6c6e74317564ec978030ec6a4310b0125dd65

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Long Cai
2. Masatoshi Nei
3. V. Corces
4. Tom Misteli
5. M. Nozawa
6. Yoshihito Niimura
7. Claude Desplan
8. R. Losick

In Nutrition and Dietetics

1. V. Corces
2. Tom Misteli

In Sensory Systems

1. V. Corces
2. Tom Misteli

Citations in the corpus

• Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C) (2006, background): “These data provided further evidence for spatial interactions between distant olfactory receptor gene cluster”
• Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus (2018, background): “These observations, and others (Branco and Pombo, 2006; Lomvardas et al., 2006), demonstrate that genome interactions can occur beyond chromosome territories and organize around nuclear bodies.”
• Stochasticity and Cell Fate (2008, background): “of the olfactory receptor genes in the genome [ 27 ].”
• CTCF: Master Weaver of the Genome (2009, positive): “…instances long-range chromatin contacts have been linked to important biological processes such as olfactory receptor choice (Fuss et al., 2007; Lomvardas et al., 2006), monoallelic gene expression (Apostolou and Thanos, 2008; Ling et al., 2006), X chromosome inactivation (Bacher et al., 2006;…”
• The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity (2008, background): “In mice, a group of OR genes exists as a cluster on a chromosomal region, and it has been suggested that any one of these genes is randomly chosen to be expressed in each olfactory neuro”
• Chromosome territories. (2010, background): “To date, numerous spatial interactions of CTs were reported in cis and trans (Ling et al. 2006; Lomvardas et al. 2006; Babu et al. 2008).”
• Nuclear organization of the genome and the potential for gene regulation (2007, background): “A quarter of sequences identified as interacting with this element by 4C analysis were immediately upstream of olfactory-receptor gene”
• Enhancer function: new insights into the regulation of tissue-specific gene expression (2011, positive): “In some cases, they can even activate transcription of genes located in a different chromosom”
• Beyond the sequence: cellular organization of genome function. (2007, positive): “Similarly, in sensory neurons a single odorant receptor from a large repertoire is selected for expression by physical association of an odorant-receptor-enhancer element on chromosome 14, with the selected receptor localized on another chromosome (Lomvardas et al., 2006; Figure 3B).”
• Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “1130 Cell 136, 1122–1135, March 20, 2009 ª2009 Elsevier Inc. pursuing this further is outside the scope of the present study, such a mechanism has been shown for other gene complexes (Dillon and Grosveld, 1993; Lomvardas et al., 2006).”
• Cellular heterogeneity: when do differences make a difference? (2010, background): “…of a specific molecule from a large repertoire of possibilities generates enormous diversity by individual cell variation, such as seen for odorant, cell adhesion, or immune molecules (Coufal et al., 2009; Lomvardas et al., 2006; Morishita and Yagi, 2007; Muotri et al., 2005; Ribich et al., 2006).”
• Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, background): “Interactions between regulatory elements and target genes that are located on different chromosomes can also occur, as shown by the recent finding that an enhancer element that is present as a single copy in the genome contacts only one of the ∼1,300 olfactory receptor (OR) genes in any given sensor”
• A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Additionally, the total number of genes enriched for H3K36me3 is significantly lower than the number enriched for modifications associated with transcription initiation (Figures 4D and 4E).”
• The mammalian epigenome. (2007, background): “A recent study implicated CpA methylation as means for allelic exclusion in sensory neurons (Lomvardas et al., 2006).”