Stochasticity and Cell Fate

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How researchers see this paper

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Natural Agency: The Case of Bacterial Cognition (2017, background): “Cells are able to integrate a variety of internal and external stochastic signals from past and present conditions (Losick and Desplan 2008) to anticipate future conditions and respond accordingly (Tagkopoulos et al. 2008; Perkins and Swain 2009).”
Robustness: mechanisms and consequences (2009, background): “For example, bistable loops yield sigmoidal responses via mutual repression by two regulators [37].”
Cellular heterogeneity: when do differences make a difference? (2010, background): “However, cell-to-cell differences can have functional consequences, such as seen for cell fate decisions in the bacterium Bacillus subtilis and selection of color vision photoreceptors in Drosophila (Losick and Desplan, 2008).”
Analyzing Fluctuating Asymmetry with Geometric Morphometrics: Concepts, Methods, and Applications (2015, background): “Such differences can occur because of the stochasticity of molecular processes due to the low number of copies of DNA and many other molecular species within cells and can translate to variability across developing tissues and organs [323–327].”
Droplet barcoding for single cell transcriptomics applied to embryonic stem cells (2015, neutral): “Still other expression changes appear to be stochastic in nature (Paulsson, 2005; Swain et al. 2002), and may have important consequences (Losick and Desplan, 2008).”