Nuclear organization of the genome and the potential for gene regulation

By Peter Fraser, Wendy A. Bickmore. Nature, 2007

761 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0bf645f4637f1525c0d9513f95390157616409d8

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Citations in the corpus

The Role of Snail in EMT and Tumorigenesis (2013, background): “In the eukaryotic nucleus, DNA is packaged with core histones and other chromosomal proteins to form chromatin [66-68].”
Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture (2011, methodology): “Chromosomal organization has therefore been explored for many decades using methods that vary in scale and resolutio”
Theoretical and computational hierarchical nanomechanics of protein materials: Deformation and fracture (2008, background): “as a glue), assemblies of weak non-covalent bonds governs structural organization and function [1,2,12,24] of these materials.”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “…been proposed to come together in shared regions of ongoing transcription (often referred to as transcription factories) (de Laat and Grosveld, 2007; Fraser and Bickmore, 2007), suggesting that transcriptional activity is a major determinant in the higher-order folding of the genome in eukaryotes.”
CTCF: Master Weaver of the Genome (2009, neutral): “Principles behind these techniques and their limitations are discussed in detail elsewhere (Dekker, 2006; Fraser and Bickmore, 2007).”
The Ensembl Regulatory Build (2015, background): “In particular, it determines which regions are accessible to outside molecules [11], and which regions are in physical proximity to each other despite being distant in the genomic sequence [12].”
Hierarchical cooperation of transcription factors from integration analysis of DNA sequences, ChIP-Seq and ChIA-PET data (2019, background): “The spatial structure of the genome is important to cellular functions, such as gene expression and regulation, cell differentiation and identity, and tissue development [1 – 3].”
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2013, neutral): “In many cases, long-range DNA interactions are involved in regulating gene expression (Fraser and Bickmore, 2007).”
Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. (2009, background): “…separation of transcriptionally active and inactive chromatin (Kosak et al., 2007; Lanctot et al., 2007), as well as direct spatial nuclear interactions between genes (Fraser and Bickmore, 2007; Sexton et al., 2007), was recently recognized as an important factor in transcriptional regulation.”
Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “Large-scale folding of chromatin may affect gene expression by locating genes to specific nuclear subcompartments that are either stimulatory or inhibitory to transcription (Dekker, 2008; Fraser and Bickmore, 2007).”
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells (2009, background): “Although gene associations at factories seem to be dynami”
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. (2013, neutral): “Seminal microscopy studies have linked the spatial positioning of specific genomic loci to gene expression (Fraser and Bickmore, 2007; Kosak and Groudine, 2004; Lanctôt et al., 2007), replication (Gilbert et al.”
Chromosome territories. (2010, methodology): “4D) (Fraser and Bickmore 2007).”
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. (2008, neutral): “Positions within these territories appear to be related to the control of gene expression and other nuclear activities (Fraser and Bickmore 2007; Lanctot et al. 2007).”