Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

By M. Simonis, P. Klous, Erik Splinter, Y. Moshkin, R. Willemsen, E. D. Wit, B. van Steensel, W. de Laat. Nature Genetics, 2006

1,398 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e4c201d7f88d57931dbde0eea87c67f3efa2dcca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Leonid A. Mirny
2. Job Dekker
3. Bing Ren
4. W. de Laat
5. Nezar Abdennur
6. Ming Hu
7. Anthony D. Schmitt
8. E. de Wit

In Plant Science

1. Leonid A. Mirny
2. Nezar Abdennur
3. Bing Ren
4. Job Dekker
5. W. de Laat
6. Ming Hu
7. Anthony D. Schmitt
8. E. de Wit

Citations in the corpus

• Chromosome territories. (2010, methodology): “…of specific genomic loci is the technique of “chromosome conformation capture” (3C) introduced by Dekker et al. (2002) and its recent extension to 4C (chromosome conformation capture-on-chip [Simonis et al. 2006] and “circular chromosome conformation capture” [Zhao et al. 2006]), respectively.”
• Functional and mechanistic diversity of distal transcription enhancers (2011, positive): “This approach has been adapted to produce genome-wide maps of the threedimensional associations that a specific locus makes among all of the other sequences in the genome (‘‘4C’’) (Zhao et al., 2006; Simonis et al., 2006) or even associations among multiple sequences located throughout the genome (‘”
• Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “More recent technical developments have focused on higher-throughput analyses and these include circular chromosome conformation capture (4C) [66,67], chromosome conformation capture carbon copy (5C) [68], combined 3C-ChIP-cloning (6C) [69], chromatin interaction analysis with paired-end tag sequenc”
• ChIA-PET tool for comprehensive chromatin interaction analysis with paired-end tag sequencing (2010, methodology): “Our validations, including 3C [13], ChIP-3C [16], and 4C [17], as well as fluorescent in situ hybridization (FISH) and small interfering RNA experiments, suggest that the majority of the intra-chromosomal chromatin interactions identified in this analysis are bona fide loci bound by ERα as reported ”
• Complex multi-enhancer contacts captured by Genome Architecture Mapping (GAM) (2017, neutral): “As expected, we found that the mean percentage coverage of NPs containing chromosomes 1, 2, 9, 11 and 14 negatively correlates with their radial position, previously measured in Mayer et al. (2005)35.”
• Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture (2011, methodology): “, and with the initial scaling of this technique to assays quantifying the contacts of one locus versus the entire genom”
• CTCF-Mediated Functional Chromatin Interactome in Pluripotent Cells (2011, methodology): “To validate the intra- and interchromosomal interactions, we applied the 4C-based molecular metho”
• Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions (2007, methodology): “A similar method that has been named 4C ( Box 1 ) has been used to characterize the spatial genomic environment of the mouse β-globin locu”