Generation and propagation of radical reactions on proteins.

By C. Hawkins, M. Davies. Biochimica et Biophysica Acta, 2001

681 citations recorded by the source corpus.

Subfields: Inorganic Chemistry, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/cc8319e0b4b7748686a962758271de1ca9bedfbb

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In Inorganic Chemistry

In Molecular Biology

In Organic Chemistry

Citations in the corpus

Relationship between lipid and protein oxidation in fish (2019, positive): “Due to side chain oxidation of some amino acids (Arg, Lys, His and Pro) or backbone oxidation of Asp, Pro and Glu residues carbonylation can be considered as a per‐ manent and destructive (Hawkins & Davies, 2001) indicator of protein oxidation (Nystrom, 2005).”
Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases (2019, background): “The latter may react with another substrate to give a new carbon-centered radical and a hydroperoxide ROOH, which may decompose into alkoxyl radical RO• in a reaction catalyzed by redox competent metal cations such as iron or copper (as occurring with heme proteins [3]).”
Protein oxidation and peroxidation (2016, background): “This hydroperoxide/RO • pathway appears to compete with the imine hydrolysis route to backbone fragmentation [7,13,37].”
The oxidative environment and protein damage. (2005, background): “One of the major fates of this radical is self-dimerisation, with the formation of the cross-linked product di-tyrosine [18,22,38].”
Leaf senescence and activities of the antioxidant enzymes (2007, background): “Reaction of most ROS with proteins results in the initial formation of carbon-centered radicals at either the protein backbone or side chains (Hawkins and Davies 2001).”
Role of oxygen radicals in DNA damage and cancer incidence (2004, methodology): “Several methods, ranging from chemical and physical to enzymatic techniques, may be used to generate peroxyl radicals [64].”
Protein Oxidation: Basic Principles and Implications for Meat Quality (2013, background): “For instance, proline oxidation provides a unique mechanism for peptide bond cleavage via the formation of 2-pyrrolidone, which later is hydrolyzed to 4-aminobutyric acid (Stadtman, 1993; Hawkins and Davies, 2001).”