NALPs: a novel protein family involved in inflammation
By J. Tschopp, Fabio Martinon, K. Burns. Nature reviews. Molecular cell biology, 2003
789 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cc1a0fbaec3081b2c22779302ef6f93cbd5491ec
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- J. Tschopp
- Fabio Martinon
- G. Núñez
- Annick Mayor
- G. Salvesen
- L. Franchi
- Katherine A. Fitzgerald
- T. Mak
In Molecular Biology
- J. Tschopp
- G. Núñez
- Fabio Martinon
- G. Salvesen
- L. Franchi
- Annick Mayor
- Katherine A. Fitzgerald
- S. Riedl
Citations in the corpus
- Inflammatory caspases and inflammasomes: master switches of inflammation (2007, background): “Despite the absence of a CARD, the neuronal apoptosis inhibitor protein (NAIP) shares with IPAF the highest sequence similarity of the NACHT and LRR domains, suggesting that these molecules are evolutionary and functionally related.(57) Instead of a CARD, NAIP harbors three N-terminal baculovirus in”
- The apoptosome: signalling platform of cell death (2007, background): “It has been proposed that the NACHT domains, much like Apaf-1, can form oligomeric inflammasomes to activate their target proteins through adaptor domains, such as CARD or pyrin domains”
- Caspase functions in cell death and disease. (2013, background): “Notably, human NLRP1 can also bind to caspase-5 and thereby contribute to the processing of pro-IL1b and pro-IL-18 (Tschopp et al. 2003).”
- Regulation of inflammasome signaling (2012, background): “NLRP1 also contains a FIIND (function-to-find domain), which is also present in CARD8 (Cardinal”
- Mechanisms of caspase activation. (2003, background): “In addition to apoptosis, a subgroup of the caspase family is involved in inflammation, where they act as pro-cytokine activators [1].”
- The inflammasomes: guardians of the body. (2009, background): “NALPs represent the largest NLR subfamily and have 14 genes identified in humans (29) (Table 1).”
- The inflammasomes. (2010, neutral): “It should be noted that CIITA is often annotated as harboring a CARD domain, because a splice variant expressed in dendritic cells contains adomain with homologyto CARD domains (Nickersonetal.,2001);however,thetranslatedtranscriptvariantisnotclassifiedascontainingaclassicalCARDdomainbytypicalapproach”