A novel family of mammalian taste receptors.

By E. Adler, M. Hoon, K. L. Mueller, Jayaram Chandrashekar, N. Ryba, C. Zuker. Cell, 2000

1,250 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/cbac5c211b65fbaf5ffe44231acfec4ac0b5928a

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Citations in the corpus

Molecular basis for species-specific sensitivity to "hot" chili peppers. (2002, neutral): “directed mutagenesis as previously described (Jordt et al., 2000). All constructs were verified by DNA sequencing. cDNAs were cloned Clapham, D.E., Runnels, L.W., and Strübing, C. (2001). The TRP ion into pCDNA3 or the combined oocyte/mammalian expression vector channel family.”
Common Sense about Taste: From Mammals to Insects (2009, background): “Mammalian taste receptors show markedly more sequence divergence between species than do typical GPCRs (Adler et al., 2000; Nelson et al., 2001).”
The receptors and cells for mammalian taste (2006, background): “Bitter taste is mediated by a family of ∼30 highly divergent GPCRs (the T2Rs”
Mammalian G proteins and their cell type specific functions. (2005, background): “The T2 receptors are a group of 30 GPCRs that are specifically expressed in taste buds of the tongue and that are linked to bitter taste in mice and humans (6, 78, 94, 429).”
The molecular receptive ranges of human TAS2R bitter taste receptors. (2010, background): “T2R) gene family encoding bitter taste receptor candidates (Adler et al. 2000; Chandrashekar et al. 2000; Matsunami et al. 2000; Mueller et al. 2005; Behrens et al. 2007).”
Bitter taste, phytonutrients, and the consumer: a review. (2000, background): “A very recent discovery of a novel family of bitter-taste receptors placed the number of gustducin-linked bitter taste receptors in humans as high as 40–80 (42, 43).”
T2Rs function as bitter taste receptors. (2000, background): “The high selectivity of T2R-5 for gustmine how this is achieved and whether nerve terminalsducin, and the exclusive expression of T2Rs in taste provide any instructive signals for the expression of T2Rreceptor cells that contain gustducin (Adler et al., 2000), receptors.”
An overview of binary taste–taste interactions (2003, background): “Given that various receptors and transduction mechanisms may exist for a single taste quality (Adler et al., 2000; Chandrashekar et al., 2000; Lindemann, 2001; Nelson et al., 2001), it is possible that”
Bioactive protein hydrolysates in the functional food ingredient industry: Overcoming current challenges (2017, background): “Each taste modality is thought to be mediated by different transduction pathways expressed in different subsets of receptors.((101)) Bitter taste”
Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer (2009, background): “The oral sensing of the molecules evoking the bitter taste in foods is mediated in humans by a family of ~25 recently discovered G-proteincoupled receptors encoded by the TAS2R gene family (Adler et al. 2000; Behrens et al. 2007; Chandrashekar et al. 2000; Matsunami et al. 2000; Meyerhof 2005).”
The cell biology of taste (2010, background): “On the basis of in situ hybridizations with mixed probes on rodent taste buds, the T2Rs were reported either to be expressed as overlapping subsets of mRNAs (Matsunami et al., 2000) or coexpressed in a single population of taste cells (Adler et al., 2000).”
Receptors and transduction in taste (2001, background): “By scanning genomic databases near a promising bitter locus on mouse chromosome 6, a group of new GPCRs was discovered, the T2R famil”
Bitter taste transduced by PLC-β2-dependent rise in IP3 and α-gustducin-dependent fall in cyclic nucleotides (2001, background): “In this construct, the bitter stimuli interact with 7TM receptors, most likely those recently identified (1, 11).”