Bitter taste transduced by PLC-β2-dependent rise in IP3 and α-gustducin-dependent fall in cyclic nucleotides

By Wentao Yan, G. Sunavala, S. Rosenzweig, M. Dasso, J. Brand, A. Spielman. 2001

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Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores (2010, background): “All tastes are detected and perceived via these taste receptors, which mediate signal cascades through second messenger molecules [45-49].”
Contribution of α-Gustducin to Taste-guided Licking Responses of Mice (2005, background): “Once these taste receptors are activated by their respective ligands, they activate one or more G-proteins (gustducin, rod-transducin or Gi2), which in turn stimulate one or more effector systems (adenylyl cyclase, phosphodiesterase or phospholipase C b2; Huang et al., 1999; Clapp et al., 2001; Yan ”
Umami Taste Responses Are Mediated by α-Transducin and α-Gustducin (2004, background): “In contrast, rat circumvallate papillae taste tissues responded to MSG and L-AP-4 by decreasing cAMP (Abaffy et al., 2003), as is the case with bitter compounds (Lindemann, 1996; Yan et al., 2001).”