Molecular basis for species-specific sensitivity to "hot" chili peppers.

By S. Jordt, D. Julius. Cell, 2002

880 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/60c96f4cbab66851a86d18375fb811423efd7cc8

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In Cellular and Molecular Neuroscience

In Nutrition and Dietetics

In Sensory Systems

Citations in the corpus

Peroxidases and the metabolism of capsaicin in Capsicum annuum L. (2004, background): “Finally, it must be noted that birds are not sensitive to capsaicinoids, due to the characteristics of their vanilloid receptors ( Julius and Jordt, 2002 ).”
The Influence of Plant Secondary Metabolites on the Nutritional Ecology of Herbivorous Terrestrial Vertebrates (2005, background): “Recent studies confirm that molecular differences in the vanilloid receptor between birds and mammals may explain why mammals but not birds are repelled by a hot, peppery taste (Jordt & Julius 2002).”
Anandamide and vanilloid TRPV1 receptors (2003, background): “While the wild-type VRL-1 receptor does not normally bind either capsaicin or anandamide; VRL-1 receptor mutants, in which capsaicin displaces the specific binding of [3H]RTX, also have an affinity for anandamide (Jordt & Julius, 2002).”
Heat-Evoked Activation of the Ion Channel, TRPV4 (2002, background): “An analogous situation has been observed for TRPV1, in which proton-, heat-, and capsaicin-evoked responses are mechanistically distinguishable, although they interact (Jordt et al., 2000; Jordt and Julius, 2002).”
Defining and assessing animal pain (2014, neutral): “Further, some analgesic drugs are administered by veterinarians and experimenters to ameliorate apparent pain, suggesting a high evolutionary conservation of receptors for drugs such as opioids and NSAIDs (Jordt & Julius, 2002; Nasr, Nicol, & Murrell, 2012).”
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “-arrestin recruitment assays, Kapur et al. (2009) detected no sign of -THC-induced activation of GPR55, whereas Yin et al.”
Chemical activation of the mechanotransduction channel Piezo1 (2015, neutral): “…that elicits Ca2+ flux in Piezo1- but not vector-transfected cells; we named this compound Yoda1 (see ‘Materials and methods’ and Figure 1D for screen and Yoda1 details). eLife digest Within our bodies, cells and tissues are constantly being pushed and pulled by their surrounding environment.”
TRP channels and pain. (2013, background): “First, the vanilloid binding site likely specifies interaction with endogenous factors such as anandamide and other bioactive lipids that bear structural similarity to capsaicin (so-called endovanilloids) ( Jordt & Julius 2002).”