T2Rs function as bitter taste receptors.

By Jayaram Chandrashekar, K. L. Mueller, M. Hoon, E. Adler, Luxin Feng, Wei Guo, C. Zuker, N. Ryba. Cell, 2000

1,322 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/db841e3c8b1d279e236cfa62a89b3deff1b3d3d5

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In Biomedical Engineering

In Nutrition and Dietetics

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Citations in the corpus

Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores (2010, background): “Recent advancements have identified the taste receptor cells on the human tongue for the five basic tastes [38-44]; their signal pathways are shown in Figure 1.”
Mammalian sweet taste receptors. (2001, methodology): “…a familyUniversity of California at San Diego of 30 different genes that include several functionallyLa Jolla, California 92093 validated mammalian bitter taste receptors (Adler et al.,2 National Institute of Dental 2000; Chandrashekar et al., 2000; Matsunami et al.,and Craniofacial Research 2000).”
The molecular receptive ranges of human TAS2R bitter taste receptors. (2010, background): “T2R) gene family encoding bitter taste receptor candidates (Adler et al. 2000; Chandrashekar et al. 2000; Matsunami et al. 2000; Mueller et al. 2005; Behrens et al. 2007).”
Mammalian G proteins and their cell type specific functions. (2005, background): “The T2 receptors are a group of 30 GPCRs that are specifically expressed in taste buds of the tongue and that are linked to bitter taste in mice and humans (6, 78, 94, 429).”
The receptors for mammalian sweet and umami taste. (2003, background): “Zuker1,* (1)Howard Hughes Medical Institute and sors (Chandrashekar et al., 2000; Bufe et al., 2002).”
The cell biology of taste (2010, background): “For instance, receptor cells that express members of the T2R family of GPCRs sense bitter compounds (Chandrashekar et al., 2000).”
Receptors and transduction in taste (2001, background): “Three of the receptors could be expressed in a cell line, where they responded to bitter tastant”
Common Sense about Taste: From Mammals to Insects (2009, background): “Ligands for several mouse and human T2Rs have been identified in cell-based assays, and as expected, all are bitter to humans or aversive to mice (Chandrashekar et al., 2000; Bufe et al., 2002; Pronin et al., 2004; Meyerhof et al., 2005).”
An overview of binary taste–taste interactions (2003, background): “Given that various receptors and transduction mechanisms may exist for a single taste quality (Adler et al., 2000; Chandrashekar et al., 2000; Lindemann, 2001; Nelson et al., 2001), it is possible that”
Umami Taste Responses Are Mediated by α-Transducin and α-Gustducin (2004, background): “During the past few years, several GPCRs have been identified in taste cells and implicated in taste signal transduction (Adler et al., 2000; Chandrashekar et al., 2000; Chaudhari et al., 2000; Max et al., 2001; Nelson et al., 2001, 2002; Li et al., 2002).”
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. (2001, neutral): “(Chandrashekar et al., 2000).”
Contribution of α-Gustducin to Taste-guided Licking Responses of Mice (2005, background): “A few T2Rs have been shown to respond selectively to compounds that elicit bitter taste sensations in humans (Adler et al., 2000; Chandrashekar et al., 2000; Bufe et al., 2002).”