Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

By J. Suh, Swapna V Shenvi, Brian M. Dixon, Honglei Liu, Anil K. Jaiswal, Rui‐Ming Liu, T. Hagen. Proceedings of the National Academy of Sciences of the United States of America, 2004

763 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cade4de618f4909ddcfd2a92875ed87738d9902a

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Citations in the corpus

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential (2009, background): “The interaction of LA and intracellular signaling is perceived to account for LA's beneficial effects observed at 24h post-administration [5,80], a time point that is much delayed from the plasma LA Tmax of ~1h [18].”
Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. (2010, background): “levels declined by over 50% in old rats (24 months) relative to young rats (3 months) [74].”
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway (2006, background): “injury, inflammation, emphysema, asthma, lupus-like autoimmune nephritis, and macular degeneration (Aoki et al., 2001; Yoh et al., 2001; Braun et al., 2002; Cho et al., 2002; Cho et al., 2004; Gao and Talalay, 2004; Suh et al., 2004; Ishii et al., 2005; Rangasamy et al., 2005; Shih et al., 2005a; Sh”
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. (2008, background): “It was previously reported that the transcriptional activity of Nrf2 decreases in aging mice (Suh et al., 2004).”
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. (2006, background): “(40) showed that aged rats have reduced levels of GSH and diminished expression of GSH-biosynthetic enzymes (GCLC and glutamate cysteine ligase, modifier subunit [GCLM]) as a result of a decline in the transcriptional activity of Nrf2.”
Mechanisms of Vascular Aging (2018, background): “detoxify ROS and repair ROS-induced macromolecular damage.(93) In the young vasculature, this adaptive homeostat-”
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner (2011, background): “Indeed, it has been reported that lipoic acid restores the decline in glutathione levels and Nrf2 transcriptional activity that occurs with aging (43).”
Redox Regulation of Cell Survival (2008, neutral): “Recent study suggested that this phenomenon may be caused by attenuation of Nrf2/ARE transcriptional activity (289).”