Endogenous ligands of Toll‐like receptors

By M. Tsan, Baochong Gao. Journal of Leukocyte Biology, 2004

749 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/ca248c9323a5f6d3135044db2580f9d90c8b80ff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Marshak‐Rothstein
2. J. Powell
3. Shizuo Akira
4. Taro Kawai
5. R. Medzhitov
6. K. Takeda

In Immunology

1. H. Kono
2. K. Rock
3. A. Marshak‐Rothstein
4. Shizuo Akira
5. DM Mosser
6. X. Zhang
7. R. Medzhitov
8. T. Mogensen

Citations in the corpus

• Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR21 (2006, background): “Recently, however, the ability of endogenous ligands to stimulate via TLRs has come into question due to possible contamination with LPS and lipoproteins (50, 51).”
• Toll-like receptors in systemic autoimmune disease (2006, background): “Although the data on endogenous ligands might, in some cases, be confounded by low-level contamination with microbial products 6 , it is clear that this is not always the case.”
• Macrophage activation by endogenous danger signals (2008, background): “∗ Concerns of possible LPS contamination remain for some of these ligands [160].”
• Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock (2007, background): “However, the biological relevance of potential endogenous TLR4 ligands has been a matter of debat”
• How dying cells alert the immune system to danger (2008, background): “In the case of extracellular PAMPs, some of the most important sensors are TLR”
• Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. (2006, background): “In addition to the importance of TLRs in sensing pathogen-associated molecular patterns, a number of endogenous TLR ligands have been described (Tsan and Gao, 2004).”
• Identification of a key pathway required for the sterile inflammatory response triggered by dying cells (2007, neutral): “The finding that Tlr2 and Tlr4 have a small role in sensing and transducing inflammatory signals from injured cells is consistent with reports that they recognize some mammalian molecules potentially released from dying cell”