Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

By T. Vogl, K. Tenbrock, S. Ludwig, Nadja Leukert, C. Ehrhardt, M. V. Zoelen, W. Nacken, D. Foell, T. Poll, C. Sorg and 1 more. Nature Medicine, 2007

1,421 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/449f0155e324615b5e473420b069ac047b594da9

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In Molecular Biology

In Pulmonary and Respiratory Medicine

Citations in the corpus

DAMPening Inflammation by Modulating TLR Signalling (2010, background): “Lethal sepsis (LPS ) Protects from lethality [143]”
The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. (2016, background): “phils and monocytes/macrophages during inflammatory conditions and signal via RAGE and TLR4 receptors.(43,44) Humans Table.”
Functions of S100 Proteins (2012, background): “One report indicates that S100A9 induces TNF- , IL-1 , IL-6 and IL-8 in macrophages via NF- B activation [228] whereas another claims that it principally activates neutrophils via TLR-4 [60] and S100A9 decreases phorbol-12-myristate-13-acetate-triggered peroxide production by BCG-activated macrophag”
A CXCL1 paracrine network links cancer chemoresistance and metastasis (2012, positive): “Binding of S100A8/9 to receptors RAGE and TLR4 can activate diverse signaling cascades (Gebhardt et al., 2006; Ichikawa et al., 2011; Vogl et al., 2007).”
Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “However, calprotectin has been reported to be expressed by other myeloid and epithelial cells and to be involved in numerous other immune-related functions, such as chemotaxis, regulation of the NADPH oxidase complex, activation of Toll-like receptor 4 and induction of apoptosis [35,58,59,60].”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “These receptors include heparan sulfate (18), TLR4 (19), and carboxylated N-glycans (20).”
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas (2021, positive): “As ANXA1-FPR1 and S100A9/A8-TLR4 interactions have been reported to play critical roles in the recruitment of immune cells and inflammatory cascade in sepsis and tumors (Gavins et al., 2012; Laouedj et al., 2017; Osei-Owusu et al., 2019; Vogl et al., 2007), we hypothesize that they might also play i”
The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer (2009, background): “Recently, S100A8 and S100A9, two members of the S100 protein family, have been identified as important DAMPs released by activated phagocytes and recognized by TLR4 on monocytes [10].”
S100A8/A9 in Inflammation (2018, background): “S100A9−/− mice are less sensitive to LPS stimulation and more resistant to LPS-induced septic shock (69).”
Inflammation in Atherosclerosis: From Pathophysiology to Practice (2009, background): “For example MRP-8/14 can bind TLR-4, activating innate immunity through this pattern recognition receptor.(23)(Figure 2) This ligand can also promote endothelial cell apoptosis, a process implicated in plaque thrombosis.”
Macrophage activation by endogenous danger signals (2008, background): “Recently, Vogl et al demonstrated a pivotal role of these proteins in enhancing LPS-induced phagocyte activation via their interaction with TLR4 in models of LPSinduced shock and Escherichia coli-induced abdominal sepsis [101].”