How dying cells alert the immune system to danger

By H. Kono, K. Rock. Nature reviews. Immunology, 2008

1,803 citations recorded by the source corpus.

When a cell dies in vivo, the event does not go unnoticed. The host has evolved mechanisms to detect the death of cells and rapidly investigate the nature of their demise. If cell death is a result of natural causes — that is, it is part of normal physiological processes — then there is little threat to the organism. In this situation, little else is done other than to remove the corpse. However, if cells have died as the consequence of some violence or disease, then both defence and repair mechanisms are mobilized in the host. The importance of these processes to host defence and disease pathogenesis has only been appreciated relatively recently. This article reviews our current knowledge of these processes.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5ef97acdc2c8a3eaf13d32f14efa1d053f4d07bf

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Citations in the corpus

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “Thus, it is very likely that this early necrotic cells trigger an inflammatory response (Kono and Rock 2008).”
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Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells (2011, background): “Recently, it has been shown that dsDNA can be released from necrotic cells, reach the cytoplasm of APCs, and be recognized by a TLR-independent on January 17, 2012 jem .rupress.org D ow nloaded from JEM Vol. 208, No. 10 Article 2013 of type I IFNs, which are already FDA approved for other indication”
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