Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

By S. Pluchino, Lucia Zanotti, Barbara Rossi, E. Brambilla, L. Ottoboni, G. Salani, Marianna Martinello, A. Cattalini, A. Bergami, R. Furlan and 3 more. Nature, 2005

790 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/6a1c2f588b813d6a5dcdf7053d8396fa4672be82

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. S. Pluchino
2. G. Martino
3. M. Schwartz
4. Z. Kokaia
5. P. Carpentier
6. C. ffrench-Constant
7. O. Lindvall
8. L. Bonfanti

In Genetics

1. P. Carpentier
2. Robin J. M. Franklin
3. T. Palmer

In Neurology

1. Z. Kokaia
2. O. Lindvall
3. P. Carpentier
4. C. ffrench-Constant
5. M. Schwartz
6. Robin J. M. Franklin
7. Stephen L. Hauser
8. T. Palmer

Citations in the corpus

• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “, CCR1, CCR2, CCR5, CXCR3, CXCR4) on NPC surface (143, 177).”
• Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “…Palazuelos et al., 2008; Zhang et al., 2009) Cell-based therapies Neural stem cells Improvement (Picard-Riera et al., 2002; Einstein et al., 2003; Pluchino et al., 2003; 2005; Einstein et al., 2006; Makar et al., 2008; Pluchino et al., 2009; Yang et al., 2009) Mesenchymal stem cells Improvement…”
• Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, positive): “One further study has examined NSC transplants and has shown, similar to studies in MS models (Einstein et al., 2007; Pluchino et al., 2005), that NSC transplants are protective in stroke though few new neurons were produced and there is speculation, largely on the basis of earlier reports that NSCs”
• The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. (2006, background): “In EAE, systemically injected neurospheres protected animals from paralysis; however, these beneficial effects appeared to be mediated by induction of immunoregulatory networks that reduced tissue damage, and not primarily by promotion of remyelination (Pluchino et al., 2005).”
• Remyelination in the CNS: from biology to therapy (2008, background): “However, more-recent studies suggest that most, if not all, of this beneficial effect in EAE results from the immunosuppressive effect of the neural stem cells on T-cell populations in the perivascular space of the CN”
• The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “the BBB and to significantly improve the outcome of the corresponding disease [235–242].”
• Stem cells for the treatment of neurological disorders (2006, background): “Most cells remained undifferentiated and suppressed proinflammatory mechanism”