The blood-brain barrier in brain homeostasis and neurological diseases.

By N. Weiss, F. Miller, S. Cazaubon, P. Couraud. Biochimica et Biophysica Acta, 2009

692 citations recorded by the source corpus.

Brain endothelial cells are unique among endothelial cells in that they express apical junctional complexes, including tight junctions, which quite resemble epithelial tight junctions both structurally and functionally. They form the blood-brain-barrier (BBB) which strictly controls the exchanges between the blood and the brain compartments by limiting passive diffusion of blood-borne solutes while actively transporting nutrients to the brain. Accumulating experimental and clinical evidence indicate that BBB dysfunctions are associated with a number of serious CNS diseases with important social impacts, such as multiple sclerosis, stroke, brain tumors, epilepsy or Alzheimer's disease. This review will focus on the implication of brain endothelial tight junctions in BBB architecture and physiology, will discuss the consequences of BBB dysfunction in these CNS diseases and will present some therapeutic strategies for drug delivery to the brain across the BBB.

Subfields: Neurology, Nutrition and Dietetics, Oncology

View Paper: https://www.semanticscholar.org/paper/fd78b66fa330c06d31fa477682c99a02c01d4245

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. J. Joyce
2. D. Quail

In Oncology

1. J. Joyce
2. D. Quail
3. R. Weinberg

Citations in the corpus

• The role of inflammation in the development of epilepsy (2018, background): “Using induced CD44, VCAM-1, and ICAM-1, leukocytes form endothelial membrane protrusions, called “transmigratory cups”, which assist with transendothelial migration of leukocytes across the BBB [76].”
• The microenvironmental landscape of brain tumors (2017, background): “These cells are replenished through monocytosis, particularly during tumor progression where the integrity of the BBB can be compromised and permissive to inflammation (Weiss et al., 2009).”