Toll-like receptors modulate adult hippocampal neurogenesis

By A. Rolls, R. Shechter, Anat London, Yaniv Ziv, Ayal Ronen, R. Levy, M. Schwartz. Nature Cell Biology, 2007

607 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/9c13bac5b43dc5f6963ce4a2c8bc6ff25f36b194

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. S. Pluchino
2. G. Martino
3. M. Schwartz
4. Beate Winner
5. Fred H. Gage
6. Zacharias Kohl
7. L. Bonfanti
8. A. Rolls

In Neurology

1. M. Schwartz
2. Liang Liu
3. Qing-Wu Yang
4. Fred H. Gage
5. Xiao-Yi Xiong
6. Beate Winner
7. R. Medzhitov
8. A. Rolls

In Pulmonary and Respiratory Medicine

1. J. Forbes
2. M. Cooper

Citations in the corpus

• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Corroborating the observations that LPS or LPS-induced microglia impaired neurogenesis are observations that NPCs express TLRs, and that TLR4-deficient mice express high levels of neurogenesis (191).”
• Toll-like receptors and cancer (2009, background): “In the nervous system, TLRs regulate neuronal homeostasis by controlling the proliferation and differentiation of adult hippocampal neurons in the brai”
• NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review (2015, background): “In the CNS, NF-κB transcription factors are key players in a number of physiological processes such as neurogenesis (Koo et al., 2010), neuritogenesis (Rolls et al., 2007), and synaptic plasticity which related to learning and memory (Levenson et al., 2004; O’Riordan et al., 2006; Ahn et al., 2008).”
• The bright side of the glial scar in CNS repair (2009, background): “TLRs expressed on neural progenitor cells regulate their proliferation and cell-fate decision in the adult brain and are involved in the active adult neurogenic niche and in the postnatal ey”
• Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, unknown): “…the above-mentioned studies on SCID, nude and irradiated/immunedepleted mice, but also by more common and natural conditions associated with both diminished T cell activity and cognitive impairments, such as aging, HIV infection and chemotherapy (Kipnis et al., 2008; Ron-Harel and Schwartz, 2009).”
• Mechanisms of diabetic complications. (2013, background): “Given that TLRs have also been identified in the mammalian nervous system, on cells such as glia, neurons, and neural progenitor cells (498), it is likely that these receptors also contribute to neuropathy and retinopathy, with this area warranting detailed investigation.”
• Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “This may be because LPS stimulates microglia/macrophage activation via its classical ligand TLR4, which has been demonstrated to play an important role in inhibiting hippocampal neurogenesis (Rolls et al., 2007).”
• Neurodegenerative disease and adult neurogenesis (2011, background): “In addition, there are indications that knock-down of toll-like receptor 4 (Rolls et al., 2007) and toll-like receptor 3 has a positive impact on adult neurogenesis and memory (Okun et al., 2010).”