Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine

By Venkata S. Mattay, Terry E. Goldberg, Francesco Fera, Ahmad R. Hariri, Alessandro Tessitore, Michael Egan, Bhaskar S. Kolachana, J. Callicott, Daniel R. Weinberger. Proceedings of the National Academy of Sciences of the United States of America, 2003

958 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c9c35a54a2f4d8dcdf4cbc7e07914a2d7c1eede2

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Citations in the corpus

The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. (2004, background): “…of this strategy have included assessment of the functional consequences of polymorphisms in the COMT gene on the function of the prefrontal cortex (Mattay et al., 2003), and assessment of the effects that the serotonin transporter gene polymorphism has on the sensitivity of limbic brain regions…”
Discovering Endophenotypes for Major Depression (2004, background): “Preliminary evidence for the potential heritability of these findings includes a functional polymorphism of the catechol-O-methyltransferase (COMT) gene that has been associated with the individual variation in the brain response to dopaminergic challenge (Mattay et al, 2003).”
Stress signalling pathways that impair prefrontal cortex structure and function (2009, neutral): “: the methionine substitution in the COMT protein that results from one of the COMT polymorphismsreduces the ability of COMT to catabolize dopamine and increases vulnerability to stress- or stimulant-induced working memory impairments in human subject”
The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology (2014, background): “One instance of this phenomenon is the classic inverted U-shaped curve relating arousal and performance (25).”
Executive Function: Implications for Education. NCER 2017-2000. (2016, background): “…and Gathercole 2006); overall school achievement (e.g., Bull and Scerif 2001; Bull, Espy, and Wiebe 2008; Clark, Pritchard, and Woodward 2010; Mazzocco and Kover 2007); grades (Duckworth and Seligman 2005); high school completion (Vitaro et al. 2005), and even college graduation (McClelland…”
Mechanisms of neurotransmitter release by amphetamines: a review. (2005, background): “This use remains current, especially for fighter pilots on long missions (Caldwell et al., 2003), although it has been suggested that it causes hallucinations, particularly in people with a common mutation in catecholamine-O-methyl transferase enzyme (Mattay et al., 2003).”
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. (2004, background): “Indeed, clinical studies of COMT have revealed that the Met allele, which encodes the enzyme with lower activity, is associated with better performance on tests of prefrontally mediated cognition (Egan et al. 2001; Goldberg et al. 2003; Mattay et al. 2003; Diamond et al. 2004; Nolan et al. 2004).”
The activation of attentional networks (2005, result): “These results stand in contrast with other studies that combine imaging and genetics to explore individual differences where alleles that predict higher levels of DA were associated with more efficient executive function (Egan et al., 2001; Mattay et al., 2003).”
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory (2007, background): “Recently, the inverted U has been observed in regard to genetic alterations in catecholamine-O-methyltransferase (COMT), an enzyme that breaks down DA and thus controls DA levels in PF”
Intermediate phenotypes and genetic mechanisms of psychiatric disorders (2006, background): “and the cortical response to amphetamine, which increases synaptic dopamin”
Explaining the many varieties of working memory variation: Dual mechanisms of cognitive control. (2007, background): “For example, recent work has linked variations in the COMT gene to dopaminergic function within PFC, and moreover to behavioral performance and PFC activity during cognitive control tasks, such as the n-back (Mattay et al., 2003).”
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “In the context of these findings, it is interesting that amphetamine effects on fMRI activations elicited by WCST and n-back task performance depended on COMT genotype (Mattay et al, 2003).”