Discovering Endophenotypes for Major Depression

By G. Hasler, Wayne C. Drevets, Husseini K. Manji, Dennis S. Charney. Neuropsychopharmacology, 2004

1,139 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/3efc97b3c17ace8736a9ac048376932149d85dfd

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In Behavioral Neuroscience

In Experimental and Cognitive Psychology

Citations in the corpus

Phasic and sustained fear in humans elicits distinct patterns of brain activity (2010, neutral): “In addition, unpredictable threat transiently activated the ventral amygdalaanterior hippocampus area, the anterior portion of the BNST complex, and induced dynamic signal changes in a medial prefrontal network (pregenual, subgenual, and dorsal anterior cingulate cortex, medial caudate, and medial o”
Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR*D study (2014, background): “One straightforward approach is to analyze the influences of specific depression symptoms in both clinical and research studies, instead of ignoring the information in this data (Fried et al., 2013; Hasler et al., 2004; Lux and Kendler, 2010; Van Praag, 2010).”
The Hierarchical Taxonomy of Psychopathology (HiTOP): A Dimensional Alternative to Traditional Nosologies (2017, neutral): “Third, many existing diagnoses are quite heterogeneous and encompass multiple pathological processes (Clark, Watson, & Reynolds, 1995; Hasler, Drevets, Manji, & Charney, 2004; Zim-merman, Ellison, Young, Chelminski, & Dalrymple, 2015).”
Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia (2009, methodology): “One method of addressing this challenge is the identification of psychopathological endophenotypes for psychiatric disorders, which can be used to identify specific mechanisms that may mediate the relationship between biological and environmental diatheses and clinical phenotypes[2,3].”
Comorbidity: A network perspective (2010, background): “…al. with the psychopathological endophenotype approach that has been developed to dissect major depression into different independent entities (see, e.g., Hasler et al. 2004), or with other constructs used in the field of psychiatry, such as connectionist-inspired ones (e.g., Tanti & Belzung 2010).”
Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Subjects with Major Depressive Disorder (2009, background): “This relationship provides impetus for continued investigation of depressive endophenotypes (1, 2), because it is unclear whether reduced caudate volume predisposes individuals to anhedonic or more severe depression or instead represents a state-related correlate of these symptoms.”
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques (2009, background): “Consistent with this view, anhedonia is currently considered a promising endophenotype of MDD, because it is a cardinal symptom of the disorder but is considerably more homogeneous, more easily quantified, and tied to dysfunction in the neural circuitry of reward, which is increasingly well-understo”
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model (2014, background): “In recent years, anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli (APA 2000)—has emerged as one of the most promising endophenotypes of depression (Hasler et al. 2004).”
A review of depression and suicide risk assessment using speech analysis (2015, background): “Physiological biomarkers include galvanic skin responses (Schneider et al., 2012), cardiovascular dysregulation (Carney et al., 2005), saccadic eye movements (Steiger and Kimura, 2010) and changes in REM sleep parameters (Hasler et al., 2004).”