Intermediate phenotypes and genetic mechanisms of psychiatric disorders

By Andreas Meyer-Lindenberg, Daniel R. Weinberger. Nature Reviews Neuroscience, 2006

1,216 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/40a978f1147b76043f8d3794ef974f382836f58b

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Citations in the corpus

The Neurobiology of Anhedonia and Other Reward-Related Deficits (2011, background): “Recently, there has been increased focus on understanding the neurobiology of specific behavioral dimensions, such as hedonic capacity, that are altered in psychiatric patients (reviewed in [15–20]).”
Genetic and Environmental Transmission of Political Attitudes Over a Life Time (2009, background): “…analyses may include sex differences (e.g., Hatemi, Medland, and Eaves 2009), epigenetic effects (gene expression), neurological processes (e.g., Meyer-Linderberg and Weinberger 2006), hormonal moderators, as well as gene-environment correlation (rGE) and gene by environment interaction…”
Test-retest reliability of evoked BOLD signals from a cognitive-emotive fMRI test battery (2012, background): “, 2011a, 2011b; Wise and Preston, 2010; Wise and Tracey, 2006), potentially combined with specific genotypes as an imaging intermediate phenotype (Meyer-Lindenberg, 2010; Meyer-Lindenberg and Weinberger, 2006).”
Abnormal neural oscillations and synchrony in schizophrenia (2010, background): “Neural oscillations could therefore be considered an ideal intermediate phenotype that potentially allows the direct mapping of genetic mechanisms of schizophrenia onto the neurobiolog”
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort (2010, background): “Recent advances in brain imaging and high throughput genotyping techniques enable new approaches to study the influence of genetic variation on brain structure and function (Bearden et al., 2007; Cannon et al., 2006; Glahn et al., 2007a; Meyer-Lindenberg and Weinberger, 2006; Potkin et al., 2009a).”
Arc Regulates Experience-Dependent Persistent Firing Patterns in Frontal Cortex (2014, background): “Deficits in NMDAR-signaling pathways and frontal persistent activity have long been implicated in the pathophysiology of psychiatric disorders (Meyer-Lindenberg and Weinberger, 2006; Castner and Williams, 2007; Lewis and González-Burgos, 2008).”
Practitioner Review: What have we learnt about the causes of ADHD? (2013, result): “These studies, that include a meta-analysis, suggest that the COMT val158met variant in normal individuals is associated with performance on executive function measures and emotional dysfunction (Mechelli et al., 2009; Meyer-Lindenberg & Weinberger, 2006; Mier, Kirsch, & Meyer-Lindenberg, 2010).”
Social Cognitive Neuroscience of Empathy: Concepts, Circuits, and Genes (2012, background): “Imaging genetics investigates effects of genetic variants on brain activation in circuits that are known to be involved in specific psychological functions (Esslinger et al., 2009; Meyer-Lindenberg & Weinberger, 2006).”
Spatiotemporal transcriptome of the human brain (2011, background): “However, in addition to giving us remarkable cognitive and motor abilities, the formation of molecularly distinct and intricate neural circuits may have also increased our susceptibility to certain psychiatric and neurological disorder”
Visualization of Group Inference Data in Functional Neuroimaging (2009, background): “2007), as it is frequently done in the emerging field of imaging genomics (Meyer-Lindenberg and Weinberger 2006).”
Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “Major advances in alcohol research have been made as a result of progress in human neuroimaging, particularly when used in combination with psychopharmacology and molecular genetics (315, 513).”
Long story short: the serotonin transporter in emotion regulation and social cognition (2007, background): “This concept has catalyzed seminal work integrating neuroimaging and molecular genetics in psychiatric researc”