The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes

By Robert M. Bilder, J. Volavka, Herbert M. Lachman, Anthony A. Grace. Neuropsychopharmacology, 2004

794 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/defec04d4d9268b8031ef88ac746379dc3202334

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Bradley R. Postle
2. Mark D'Esposito
3. Trevor W. Robbins
4. A. Arnsten
5. J. van Os
6. Justin Riddle
7. Michael J Frank
8. B. Buchsbaum

In Psychiatry and Mental health

1. J. van Os
2. Trevor W. Robbins
3. J. Dalley
4. Joseph E LeDoux

Citations in the corpus

• Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives (2007, background): “Bilder et al. (2004) hypothesize that the COMT Met allele, associated with low enzyme activity, results in increased levels of tonic dopamine (DA) and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically, leading to increased stability but decreased…”
• THE COGNITIVE NEUROSCIENCE OF WORKING MEMORY (2007, background): “Conversely, dopamine receptor stimulation in the striatum would promote flexibility by allowing the updating of newly relevant representations (Frank et al. 2001, Bilder et al., 2004).”
• The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation (2009, result): “The finding of impaired working memory function in val-val individuals is consistent with the classic inverted-U-shaped dogma (Egan et al. 2001) but also with the view that the val-val phenotype may be associated with enhanced distractibility and switching (Bilder et al. 2004).”