Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

By C. Lock, G. Hermans, R. Pedotti, A. Brendolan, Eric Schadt, Hideki Garren, A. Langer-Gould, S. Strober, B. Cannella, J. Allard and 9 more. Nature Medicine, 2002

1,771 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/c9474771f0bd49d74ee4d03266a9ca5172357f16

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Citations in the corpus

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, methodology): “MS lesions were characterized according to Lock et al. (2002), using Luxol Fast Blue to assess demyelination, SMI-31 IHC to assess preservation of axons, and LN3 IHC to assess inflammatory cell activity.”
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. (2008, background): “Expression of IL-17 in astrocytes may explain the marked up-regulation of the IL-17 gene noted in microarray studies of chronic MS lesions.(22) Indeed, not only was IL-17 mRNA detected in an earlier study in astrocytes cultured from adult donors in a gene array analysis,(37,42) but it was also up-re”
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “EAE is primarily used as an animal model of autoimmune inflammatory diseases of the CNS, and it resembles MS, the prototypical such disease, in many respects (Gold et al., 2006; Steinman and Zamvil, 2005; 2006; Farooqi et al., 2010).”
IL-17 and Th17 Cells. (2009, background): “IL-17 and IL-6 are among the most highly expressed genes in multiple sclerosis lesions (125), and elevated levels of IL-17 have been reported in”
Costimulatory molecule ICOS plays a critical role in the development of TH-17 and follicular T-helper cells by regulating c-Maf expression and IL-21 production (2008, background): “1690" language="eng" relation="no"> Interleukin 17 (IL-17)-producing helper T cells (T H -17 cells) have been described as a functionally new CD4 helper T cell subset that is important in the pathogenesis of many organ-specific autoimmune diseases in animal models, and higher IL-17 expressi”
The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “IL-17A is upregulated in central nervous system lesions of patients with multiple sclerosis (MS) (Lock et al., 2002).”
Multiple sclerosis: a complicated picture of autoimmunity (2007, background): “, and along with IL-6, it is also more abundant in the brain tissue of patients with multiple sclerosi”
Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity1 (2007, background): “TH17 cells have been positively correlated to the pathophysiology of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis in experimental murine models, as well as in humans (19, 20).”
The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “Under homeostatic conditions, IL-17A is present in extremely low or undetectable concentrations in human sera but has been reported to be overproduced at the both serum and tissue level in inflammatory bowel diseases, MS, and RA; (Kotake et al., 1999; Matusevicius et al., 1999; Lock et al., 2002; Fu”
Immunology of multiple sclerosis. (2005, neutral): “(36) found increased transcription of MHC class II molecules; complement; T cell and B cell genes; some cytokine genes (IL-17), as well as their receptors (IL-1R, TNF p75 receptor); and glial fibrillary acidic protein (GFAP) and transcription factors.”