Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.

By G. Galati, P. O'Brien. Free Radical Biology & Medicine, 2004

1,123 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/c5dbd9d2529ad1ddf4af66435b9535c9f966db22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Isabel C. F. R. Ferreira
2. Márcio Carocho
3. C. Winterbourn
4. Yanbo Zhang
5. Wu-yang Huang
6. Yi-Zhong Cai

In Molecular Biology

1. Isabel C. F. R. Ferreira
2. Márcio Carocho
3. C. Winterbourn
4. Han-Ming Shen
5. Yi-Zhong Cai
6. Leslie B. Poole

In Pathology and Forensic Medicine

1. C. Winterbourn

Citations in the corpus

• Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “Furthermore, many of these compounds are oxidized by peroxidases to radicals that are not always innocuou”
• A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. (2007, background): “Galati and O’Brien (2004) also reviewed the ability of certain flavonoids to prevent tumor development and also raised the possibility of flavonoid–drug interactions.”
• A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. (2013, background): “The presence of O2 and transition metals like iron and copper catalyze the redox cycling of phenolics and may lead to the formation of ROS and phenoxyl radicals which damage DNA, lipids and other biological molecules (Galati and O’Brien, 2004).”
• Exogenous antioxidants—Double-edged swords in cellular redox state (2010, background): “It was revealed that EGCG in the presence of transition metals causes oxidative damage to isolated and cellular DNA.(53) Dietary antioxidants such as phenolics can display prooxidant activities in the presence of metal ions owing to their reducing capacity and forming chelates, such as with the tran”
• Luteolin, a flavonoid with potential for cancer prevention and therapy. (2008, background): “Although the ability of flavonoids to protect cells from oxidative stress has been welldocumented, there is increasing evidence for their pro-oxidant property [25,26].”
• Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention (2009, background): “In fact, toxic flavonoids and drug interactions, liver failure, dermatitis, and anemia were reported for some cases of polyphenol chemopreventive use ( 115 ).”
• Effects of Dietary Grape Seed Proanthocyanidins on Growth Performance, Some Serum Biochemical Parameters and Body Composition of Tilapia (Oreochromis Niloticus) Fingerlings (2014, background): “The excessive intake of GSPs and other flavonoids have been suggested to exert adverse effects on the body by acting as prooxidants that generate free radicals and induce biological damage (Fine, 2000; Galati and O’Brien, 2004; Bando et al., 2007).”