Selective degradation of mitochondria by mitophagy.

By Insil Kim, S. Rodríguez-Enríquez, J. Lemasters. Archives of Biochemistry and Biophysics, 2007

1,613 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c4477132962ce274e341608b58e772787f720882

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. R. Youle
5. E. White
6. Katherine R Parzych
7. T. Johansen
8. I. Slaninová

In Geriatrics and Gerontology

1. A. Dinkova-Kostova
2. Orian Shirihai
3. A. Abramov
4. F. Platt
5. D. C. Chan
6. D. Klionsky
7. B. Boland
8. G. Shadel

In Molecular Biology

1. R. Youle
2. D. C. Chan
3. N. Mizushima
4. Beth Levine
5. E. White
6. D. Klionsky
7. Orian Shirihai
8. W. Ding

Citations in the corpus

• The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy (2008, background): “…(nair & Klionsky, 2005). autophagy also has a role in the homeostatic control of unwanted organelles such as excess peroxisomes and mitochondria, which are specifically delivered to the vacuole for degradation through pexophagy and mitophagy, respectively (Kim et al, 2007; Sakai et al, 2006).”
• Autophagy: cellular and molecular mechanisms (2010, background): “Other molecules, such as NBR1, function similarly to p62/SQSTM1 in promoting turnover of ubiquitinated proteins, while in yeast, Uth1p and Atg32 have been identified as proteins that promote selective uptake of mitochondria, a process known as mitophagy [34,44].”
• Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “has been published suggesting that damaged mitochondria might be autophagocytosed selectively in a process termed mitophagy [87].”
• The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. (2013, neutral): “degrading specific, targeted proteins [48–51].”
• An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “Mitophagy is another type of selective macroautophagy that involves the selective degradation of mitochondria, and has been shown to be important in mammals not only for steady-state turnover of these organelles (137), but also for the development of certain cell types and the clearance of damaged m”
• The emerging role of Nrf2 in mitochondrial function (2015, background): “Mitophagy, the process by which dysfunctional mitochondria are selectively engulfed by autophagosomes and delivered to lysosomes to be degraded and recycled by the cell, is essential for mitochondrial homeostasis [107,108].”
• Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, neutral): “As discussed earlier, this process has been termed ‘‘mitophagy’’ and is protective in two ways: by removing the source of toxic ROS and by degrading damaged mitochondria before they can release apoptotic factors to induce cell death (55).”
• Cellular and molecular mechanisms of mitochondrial function (2012, background): “35 This ensures that defective mitochondria are small enough to be encapsulated by lytic vesicles, autophagosomes, so that organelle content can be degraded or recycled.”
• Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “Lastly, when extreme stress causes MPT pore opening in virtually all cellular mitochondria, ATP levels drop, and, because of bioenergetic failure, neither autophagy nor apoptosis can progress, and only necrotic cell death, which is not dependent on energy supply, ensues [197].”
• PINK1- and Parkin-mediated mitophagy at a glance (2012, background): “Following their identification by PINK1, defective mitochondria are engulfed in double-membraned autophagosomes that fuse with lysosomes, thereby merging their contents Jo ur na l o f C el l S ci en ce 796 and allowing hydrolytic degradation (reviewed by Kim et al., 2007).”
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy (2008, background): “Spontaneous mitochondrial depolarization and depolarization after phototoxicity have been associated with mitophagy in mammalian cells ( Kim et al., 2007 ; Twig et al., 2008 ).”
• Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. (2008, methodology): “mitochondria it is expected to feed autophagy [7,14,15].”
• Nrf2, the Master Regulator of Anti-Oxidative Responses (2017, background): “During oxidative stress, Nrf2 might also contribute to the regulation of mitophagy, a process by which damaged mitochondria are removed, via regulation of autophagosomal degradation [68].”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “For example, the selective degradation of mitochondria is termed mitophagy (Kim et al. 2007).”
• Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy* (2012, background): “Although autophagy is generally considered to be nonspecific, it has become clear that autophagy can be selective for organelles such as mitochondria (2, 3), ER(2) (4, 5), and peroxisomes (6) under certain conditions.”