The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

By Jiefei Geng, D. Klionsky. EMBO Reports, 2008

832 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/715e865fe7613676ad8f568bbcefe4a4130cb27b

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Citations in the corpus

An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “Peroxisomes can also be degraded under starvation conditions, during which they can be specifically recognized by autophagosomes through binding of LC3-II to PEX14, a component of the peroxisomal translocon complex found on the peroxisomal membrane (39).”
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, neutral): “Formation of the autophagosome requires two ubiquitin-like conjugation systems, in which Atg12 (autophagy-related gene 12) is covalently linked to Atg5, and Atg8 is conjugated to phosphatidyletha-nolamine (Geng and Klionsky, 2008).”
LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis (2010, background): “In both systems Atg7 functions as an E1-like enzyme, whereas Atg10 and Atg3 act as E2-like enzymes for Atg12 and Atg8, respectively (Geng and Klionsky, 2008).”
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity (2010, background): “Atg7 is an E1-like protein, which activates both Atg12 and Atg8 by forming a thioester bond between Cys 507 of Atg7 and Gly 186 of Atg12 or Gly 116 of Atg8 in yeast, and the corresponding sites in the mammalian homologue”
The regulation of autophagy – unanswered questions (2011, background): “dimer of the trimeric Atg12–Atg5–Atg16 complex (Geng and Klionsky, 2008).”
Ubiquitination and selective autophagy (2012, background): “phosphatidylethanolamine (PE) by Atg3 (E2-like enzyme) (Figure 2).(46) The cysteine protease Atg4 (corresponding to deubiquitinating enzymes) has a dual role: it processes LC3 modifiers before their activation and subsequently it removes”
Glycogen and its metabolism: some new developments and old themes. (2012, background): “Yeast have a single ATG8 gene that is thought to be critically involved in the formation of autophagosomes [234].”
Regulation Mechanisms and Signaling Pathways of Autophagy (2009, background): “In contrast to ubiquitination, Atg12–Atg5 conjugation is constitutive and irreversible, and apparently no substrate-specific E3 ligase counterpart is required in this process (34).”