Developmental roles and clinical significance of hedgehog signaling.

By Andrew P. McMahon, P. Ingham, C. Tabin. Current Topics in Developmental Biology, 2003

962 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c4375013bfdb39be5df63c4d98601c4f442661af

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Citations in the corpus

Sequential roles of Hedgehog and Wnt signaling in osteoblast development (2004, methodology): “The fragment containing the cloned cDNA along with the IRES-NLS-GFP sequence was subsequently cloned into the retroviral vector pSFG (Ory et al., 1996).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “Like Eph–ephrin signalling, the sonic hedgehog ( SHH ) signalling pathway is not only required for many aspects of development (for more information, see Ref”
Mechanisms and functions of Hedgehog signalling across the metazoa (2011, background): “Diversification of HH function and deployment HHsignalling has a multitude of functions in embryonic and adult tissues: it acts as a key mediator of fundamental processes, such as cell fate specification, proliferation and patterning, as well tissue morphogenesis and homeostasis — roles that have ”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “Hedgehog (Hh) plays numerous iterative roles during embryonic development (Ingham and McMahon, 2001; McMahon et al., 2003).”
Hedgehog: functions and mechanisms. (2008, background): “All mammalian Hh proteins are thought to have similar physiological effects—the differences in their roles in development result from diverse pattern of expression (McMahon et al. 2003; Sagai et al. 2005).”
Hedgehog Signaling in Development and Cancer (2008, neutral): “Not surprisingly, malfunction of Hh signaling contributes to numerous human disorders including birth defects, such as Gorlin syndrome and Greig cephalopolysyndactyly syndrome, and cancer including basal cell carcinoma and medulloblastoma (McMahon et al., 2003; Nieuwenhuis and Hui, 2005).”
The control of chondrogenesis (2006, background): “…similar to Shh in themesenchymal condensations, activates Smo and induces Gli transcription factors, which can feed back regulate Ihh target genes in a positive (Gli1 and Gli2) or negative (Gli3) manner [Ingham and McMahon, 2001; McMahon et al., 2003; Vokes and McMahon, 2004; Tyurina et al., 2005].”
Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development (2004, neutral): “The SHH signalling molecule is crucial for a number of developmental processes, and is extensively implicated in disease (reviewed in [61]).”
Development of the endochondral skeleton. (2013, background): “The HH family of proteins plays fundamental roles in animal development and is conserved from flies to humans (Ingham and McMahon 2001; McMahon et al. 2003; Huangfu and Anderson 2006).”
Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules (2016, background): “Hedgehog (Hh) signaling has emerged as an important modulator of stem cell differentiation processes, including adipogenic differentiation, and has been shown to play crucial roles in the developmental processes of both vertebrates and invertebrates [114].”
Communicating with Hedgehogs (2005, background): “It participates in the development of numerous tissues and organ”