Sequential roles of Hedgehog and Wnt signaling in osteoblast development
By Hongliang Hu, Matthew J. Hilton, Xiaolin Tu, Kai Yu, D. Ornitz, Fanxin Long. Development, 2004
705 citations recorded by the source corpus.
Subfields: Developmental Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/118065c0d2d648b813c0108e314aac7ab83b9ee3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- T. Komori
- Fanxin Long
- D. Ornitz
- Andrew P. McMahon
- M. Goldring
- W. Birchmeier
- Stephen J. Rodda
- S. Manolagas
Citations in the corpus
- Regulation of osteoblast differentiation by transcription factors (2006, background): “Finally, conditional deletion of b-catenin gene in Dermo-Cre or Prx1-Cre transgenicmice revealed an essential role of b-catenin in osteoblast differentiation [Day et al., 2005; Hill et al., 2005; Hu et al., 2005].”
- Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2 (2019, background): “In conditional Ctnnb1 knockout mice created by crossing with Twist2 (Dermo1) Cre knock-in mice in which Ctnnb1 is deleted in osteo-chondroprogenitors, osteoblasts are absent, Runx2 is expressed in the perichondrial cells, and Sp7 expression is weak or absent in perichondrial cells [27,28].”
- Development of the endochondral skeleton. (2013, background): “Specifically, b-catenin is required for the progression from the RUNX2-positive to the OSX-positive stage, and from OSX-positive cells to mature osteoblasts (Hu et al. 2005; Rodda and McMahon 2006).”
- Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. (2005, methodology): “This results are similar to those recently published by Hu et al. (2005).”
- The control of chondrogenesis (2006, background): “Recent reports from several groups indicate that Wnt signaling, via the canonical b-catenin pathway and activation of TCF/Lef transcription factors, functions in a cell autonomous manner to induce osteoblast differentiation and suppress chondrocyte differentiation in early chondroprogenitors [Day et”
- Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors (2006, background): “…and target of canonical Wnt/ -catenin signaling in the osteoblast lineage (Hu et al., 2005), has been shown to inhibit Runx2-mediated activation of the Oc promoter; Lef1- and Runx2binding sites lie adjacent to each other in the relevant cis-regulatory region within Oc (Kahler and Westendorf, 2003).”