The staufen/pumilio pathway is involved in Drosophila long-term memory.

By Josh Dubnau, Ann-Shyn Chiang, Lori Grady, Jody Barditch, Scott Gossweiler, J. Mcneil, Patrick F. Smith, Francois Buldoc, R. Scott, U. Certa and 2 more. 2003

474 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Molecular Biology

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “The molecular and cellular mechanisms underlying aversive LTM are known to differ from those responsible for memories with shorter retention times (Yin et al., 1994; Pascual and Preat, 2001; Dubnau et al., 2003; Comas et al., 2004; Isabel et al., 2004; Yu et al., 2006; Blum et al., 2009; Akalal et a”
Dopamine Is Required for Learning and Forgetting in Drosophila (2012, positive): “(2012) found that blocking DAN activity in radish mutant flies that form only labile memories (Folkers et al., 1993) produced enhanced memory retention. This observation is consistent with our interpretation that blocking DAN activity preserves labile memories. Finally, the DAN stimulation experimen”
Olfactory memory formation in Drosophila: from molecular to systems neuroscience. (2005, background): “Numerous reviews contain detailed information about the nature of these genes and their gene products (Davis 1993, 1996; Roman & Davis 2001; Waddell & Quinn 2001; Dubnau et al. 2003a) along with the primary literature references.”
Shared Visual Attention and Memory Systems in the Drosophila Brain (2009, background): “These mutant strains were first isolated in a screen for defective LTM in an olfactory paradigm [8].”
Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body (2007, background): “In addition, several enhancer-trap transposon insertions with expression patterns exclusively outside of the mushroom body have been identified in a behavioral screen for olfactory memory mutants, although the functional relevance of these enhancer traps remains to be verifie”
Mg2+ Block of Drosophila (2012, unknown): “A CREB-dependent increase in staufen expression upon spaced training is essential for LTM formation (Dubnau et al., 2003), and we show that Mg 2+ block is required for this increase.”
Dopaminergic neurons encode a distributed, asymmetric representation of temperature in Drosophila (2013, unknown): “, 2003), w;MBGAL80;C150 (Dubnau et al., 2003), w;MBGAL80; MZ840 (Tanaka et al.”
Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (2015, background): “Several studies have identified genetic mutations that specifically affect memory 24 hr after spacedbut notmassed training (Comas et al., 2004;Didelot et al., 2006; Dubnau et al., 2003).”
Short and Long-term memory in Drosophila require cAMP signaling in distinct neuron types (2009, methodology): “For 24 hr memory experiments, animals were subjected to ten such training sessions, either massed together or spaced out with a 15 min rest interval [32, 54].”
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila (2008, methodology): “We assayed RuslanGAL4 (Dubnau et al., 2003; Wu et al., 2007) and c547 (Renn et al., 1999) that also express in EB neurons, in parallel for comparison (Fig.”
Drosophila olfactory memory: single genes to complex neural circuits (2007, background): “and mRNA transport and translation control molecules encoded by the pumilio , oskar and eIF-5C gene”
A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “We also found that krasavietzGAL4 (Dubnau et al., 2003; Shang et al., 2007) combined with MBGAL80 (Krashes et al.”
Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation (2013, background): “We have previously shown that in vivo disruptions of fragile X mental retardation (FMR), STAUFEN or PUMULIO proteins, additional molecular machinery involved in local control of mRNA translation, also yield defective LTM (27, 28).”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, unknown): “Interestingly, loss of Pumilio impairs long-term memory in Drosophila (Dubnau et al., 2003).”