Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation

By Tsung-Pin Pai, Chun-Chao Chen, Hui-Hao Lin, An-lun Chin, Jason Sih-Yu Lai, Pei-Tseng Lee, Tim Tully, Ann-Shyn Chiang. 2013

118 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Physiology

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Although several MBON cell types have been shown to play a role in associative odor memory (Sejourne et al., 2011; Pai et al., 2013; Placais et al., 2013), the functions of most MBONs have not been studied.”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “Genetic manipulation has also implicated specific subsets of MBONs in the mediation of learned appetitive and aversive behaviors (Sejourne et al., 2011; Pai et al., 2013; Placais et al., 2013; Aso et al., 2014).”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “…al., 2014; Tomchik and Davis, 2009; Wang et al., 2008; Yu et al., 2006, but see Zhang and Roman, 2013), signals in MBONs decrease in some cases (Owald et al., 2015; Séjourné et al., 2011) and increase in others (Bouzaiane et al., 2015; Owald et al., 2015; Pai et al., 2013; Plaçais et al., 2013).”
Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (2015, background): “In particular, STM is thought to be encoded in g KCs, although the only output neurons that have been described so far project from the MB vertical lobes (Séjourné et al., 2011; Pai et al., 2013).”
A connectome of a learning and memory center in the adult Drosophila brain (2017, methodology): “DANs that project to the other a lobe compartments, a2 and a3, play roles in aversive long-term memory (Aso and Rubin, 2016; Séjourné et al., 2011; Pai et al., 2013).”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “, 2012) RRID:BDSC_61645 Drosophila: G0239-Gal4 Bloomington Drosophila Stock Center; (Pai et al., 2013) RRID:BDSC_12639 Drosophila: R58E02-Gal4 Bloomington Drosophila Stock Center; (Liu et al.”
Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory (2015, unknown): “Proc Natl Acad Sci USA 107(47):20553–20558.”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “These neurons are identifiable by characterized genetic enhancer lines (Figure S1A) and were previously implicated in LTM formation or retrieval (Aso et al., 2014b; Chen et al., 2012; Pai et al., 2013; Placais et al., 2013; Sejourne et al., 2011).”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “Function of a recurrent reward circuit Prior studies on the role of MBONs in learning and memory have focused on memory retrieval (Sejourne et al., 2011; Pai et al., 2013; Placais et al., 2013; Aso et al., 2014b).”
Differential conditioning produces merged long-term memory in Drosophila (2021, background): “, and Chiang, A.S. (2013). An octopamine451 mushroom body circuit modulates the formation of anesthesia-resistant memory in 452 Drosophila. Curr Biol 23, 2346-2354. 453 Yuan, Q., Lin, F., Zheng, X., and Sehgal, A. (2005). Serotonin modulates circadian 454 entrainment in Drosophila. Neuron 47, 115-12”
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila (2015, background): “Blocking the vertical a-lobe output MB-V3/MBONa3 (n R 5, p 0.05) using G0239-GAL4 does not impair naive MCH or OCT avoidance.”
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila (2022, unknown): “To exclude developmental contributions to the observed memory defects, we repeated the immediate and 3- hr appetitive memory experiments for α5 as well as the 3- hr appetitive memory experiments for α2 knockdown animals, while suppressing RNAi expression (VT1211- Gal4>UAS- nAChRRNAi) using the tempe”
Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. (2013, methodology): “A recent work addressed the involvement of MB-V3 neurons in the retrieval of aversive memory, using the Shi protein expressed through the G0239 driver (Pai et al., 2013).”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, unknown): “Transgenic flies were raised commercially (BestGene).”