Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory.

By Emna Bouzaiane, Severine Trannoy, Lisa Scheunemann, P. Plaçais, T. Préat. 2015

157 citations recorded by the source corpus.

Understanding how the various memory components are encoded and how they interact to guide behavior requires knowledge of the underlying neural circuits. Currently, aversive olfactory memory in Drosophila is behaviorally subdivided into four discrete phases. Among these, short- and long-term memories rely, respectively, on the γ and α/β Kenyon cells (KCs), two distinct subsets of the ∼2,000 neurons in the mushroom body (MB). Whereas V2 efferent neurons retrieve memory from α/β KCs, the neurons that retrieve short-term memory are unknown. We identified a specific pair of MB efferent neurons, named M6, that retrieve memory from γ KCs. Moreover, our network analysis revealed that six discrete memory phases actually exist, three of which have been conflated in the past. At each time point, two distinct memory components separately recruit either V2 or M6 output pathways. Memory retrieval thus features a dramatic convergence from KCs to MB efferent neurons.

Subfields: Cellular and Molecular Neuroscience, Genetics, Molecular Biology

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Citations in the corpus

Dopaminergic neurons write and update memories with cell-type-specific rules (2016, background): “…Dopamine signaling to KCs has been implicated in both learning and forgetting (Schwaerzel et al., 2003; Schroll et al., 2006, Kim et al., 2007; Tomchik and Davis, 2009; Gervasi et al., 2010; Qin et al., 2012; Placais et al., 2012; Berry et al., 2012; Boto et al., 2014; Shuai et al., 2015).”
Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace (2018, unknown): “Consistent with this model, several MBOn have been implicated in the retrieval of aversive or appetitive memories and the response properties of some MBOn are altered to odors paired with rewarding or punishing US, or artificial DAn activation (Sejourne et al., 2011; Placais et al., 2013; Owald et a”
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila (2022, background): “Moreover, specific knockdown of the α5 nAChR subunit, but none of the other six α subunits, in the M4/6 MBONs (also known as MBON-γ5β’2a, MBON-β’2mp, MBON- β2β’2a, and MBON-β’2mp bilateral) – an output junction involved in coding appetitive and aversive memories (Owald et al., 2015; Bouzaiane et al.”
A connectome of a learning and memory center in the adult Drosophila brain (2017, background): “…plasticity of the KC>MBON synapse is thought to be central to associative learning in this system (Owald et al., 2015; Hige et al., 2015a; Cohn et al., 2015; Bouzaiane et al., 2015; Kim et al., 2007; Schwaerzel et al., 2003; Qin et al., 2012b; Kaun et al., 2011; Rohwedder et al., 2016).”
A Higher Brain Circuit for Immediate Integration of Conflicting Sensory Information in Drosophila. (2015, background): “Furthermore, it is possible that this mechanism applies not only to CO2 but also to other odors because the identified MBONs also respond to methylcyclohexanol and octanol [21, 42].”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “…a role in memory consolidation, and / KCs being important for LTM (Blum et al., 2009; Krashes et al., 2007; Tomchik and Davis, 2009; Trannoy et al., 2011; Yu et al., 2006) – although there are exceptions to this general picture (Aso et al., 2014b; Bouzaiane et al., 2015; Owald et al., 2015).”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “, 2004), and to be retrieved via α2sc (MB-V2) MBONs (Séjourné et al., 2011; Bouzaiane et al., 2015).”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “…al., 2014; Tomchik and Davis, 2009; Wang et al., 2008; Yu et al., 2006, but see Zhang and Roman, 2013), signals in MBONs decrease in some cases (Owald et al., 2015; Séjourné et al., 2011) and increase in others (Bouzaiane et al., 2015; Owald et al., 2015; Pai et al., 2013; Plaçais et al., 2013).”
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit. (2020, background): “In fact, it is possible to train animals by pairing the odor cue with direct activation of DANs (Aso et al. 2010, 2012; Burke & Waddell 2011; Claridge-Chang et al. 2009; Huetteroth et al. 2015; Liu et al. 2012; Schroll et al. 2006, Yamagata et al. 2015).”