Drosophila olfactory memory: single genes to complex neural circuits

By A. Keene, S. Waddell. 2007

405 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Ecology, Immunology

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “The mushroom body has been most extensively studied as a site for associative learning (Heisenberg, 2003; Keene and Waddell, 2007) in which the temporal pairing of an odor with a reinforcement experience selectively alters subsequent behavioral responses to that odor.”
WRITING MEMORIES WITH LIGHT-ADDRESSABLE REINFORCEMENT CIRCUITRY (2009, background): “In the case of the mushroom bodies, there is every expectation (though not yet formal proof) that information is stored in the weights of synapses between KCs and presently unidentified mushroom body output neurons (Dubnau et al., 2001; McGuire et al., 2001; Heisenberg, 2003; Davis, 2005; Keene and ”
Oscillatory integration windows in neurons (2016, background): “The sparse responses of KCs may facilitate association of odors with reward (Laurent, 2002; Cassenaer and Laurent, 2012), consistent with a role for the mushroom bodies in olfactory learning (Keene and Waddell, 2007).”
γ neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila (2012, neutral): “MBs integrate olfactory conditioned stimulus (CS) inputs with neuromodulatory reinforcement (unconditioned stimuli, US) [1, 2], which for aversive learning is thought to rely on dopaminergic (DA) signaling [3–6] to DopR, a D1-like dopamine receptor expressed in MBs [7, 8].”
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “, electric 157 shock), they learn the association and thereafter approach/avoid the trained odor, but not 158 untrained odors [48].”
Olfactory information processing in Drosophila. (2009, neutral): “We have omitted detailed discussion of recent advances in chemosensory transduction [4] and olfactory learning and memory [5].”
Different classes of input and output neurons reveal new features in microglomeruli of the adult Drosophila mushroom body calyx (2012, background): “In flies, the paired insect mushroom bodies are required for olfactory associative learning (e.g., Heisenberg et al., 1985) and provide a relatively simple sub- strate for the neural basis of learning and memory (Heisenberg, 2003; Keene and Waddell, 2007).”
Short and Long-term memory in Drosophila require cAMP signaling in distinct neuron types (2009, background): “Foot shock (unconditioned stimulus, US) is thought to be conveyed by dopaminergic inputs to MBs (not shown).”
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability (2012, background): “Alternatively, subcellular memory traces may interact at the circuit level via interneurons, such as the DPM and APL neurons, for which previous studies showed their essential role in memory consolidation [6,38,49,50].”
Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila (2018, background): “For processing to persist after the initial stimulus-driven phase, self-sustained, reverberant activity may come to dominate the network [42,43].”
A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body (2011, positive): “These data led us to propose that reverberant activity in a recurrent MB a0b0-to-DPM neuron circuit is required to hold labile memory and for consolidation to LTM within ab neurons [5, 9, 23, 24], where output is critical for retrieval of LTM [9, 23, 24].”
Shared mushroom body circuits underlie visual and olfactory memories in Drosophila (2014, neutral): “Cellular mechanisms underlying associative learning have been intensely studied in various animals, including Drosophila (Keene and Waddell, 2007).”
A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster (2015, background): “Elegant studies using conditional inhibition of transmitter release have provided a temporal ordering of transfer (Keene and Waddell, 2007; Cervantes-Sandoval et al., 2013; Dubnau and Chiang, 2013) leading to the idea that the role of DPM neurons is to facilitate the movement of memory from α’/β’ lo”
A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “Expression in Drosophila”