Molecular mechanisms of necroptosis: an ordered cellular explosion

By Peter Vandenabeele, L. Galluzzi, T. Vanden Berghe, Guido Kroemer. Nature reviews. Molecular cell biology, 2010

2,341 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3abb810151ab541f70c8c7efcaaad77b73ca1d27

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Citations in the corpus

Regulation of tumour necrosis factor signalling: live or let die (2015, background): “Instead, the interaction of multiple protein complexes of RIPK3 with non-ubiquitylated or de ubiquitylated RIPK1 via their RHIM domains initiates the formation of a cytosolic amyloid signalling protein complex that has been named the necrosome 99,103 .”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, neutral): “These observations as well as many of the other features of oxytosis are consistent with a recently described form of cell death called necroptosis [for review see (277)].”
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. (2011, background): “Cells can also die via necroptosis, which involves programmed activation of cell death with necrotic appearances (Vandenabeele et al., 2010).”
Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2 (2013, background): “Furthermore, recent evidence suggests that necrosis and apoptosis are integrally linked and may be different faces of a single process (necroptosis).(49) Often, dying cells manifest evidence of upregulated autophagy, an evolutionarily ancient process of ordered recycling of intracellular contents.”
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “In the presence of their ligands, death receptors elicit an intracellular signaling cascade leading to apoptotic or necrotic cell death (Vandenabeele et al., 2010).”
How Do Cytotoxic Lymphocytes Kill Cancer Cells? (2015, background): “The molecular mechanism of death receptor–induced necroptosis, which involves the kinases RIP1 (receptor-interacting protein 1) and RIP3, has been described recently (103).”
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “First, ligation of TNFR1 activates RIPK1, which in turn binds to RIPK3 via shared RIP homology interaction motifs (RHIM) present in both molecules [28, 29].”