The NF-kappaB family of transcription factors and its regulation.

By Andrea Oeckinghaus, S. Ghosh. Cold Spring Harbor Perspectives in Biology, 2009

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The complexity of NF-κB signaling in inflammation and cancer (2013, background): “Furthermore, NF-κB subunits also contain sites for phosphorylations and other post-translational modifications which are important for activation and crosstalk with other signaling pathways [11].”
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases (2017, neutral): “The phosphorylated IκB then is degraded by the proteasome allowing NF-κB subunits p65 and p50 to translocate into the nucleus [31].”
Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “The second category includes c-Rel, p65, and Rel B, which contain a transcriptional trans-activation domain (TAD).(182) Lacking TAD, the dimers formed only by p50 and p52, either homodimers or heterodimers, could not drive the transcription.”