Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.

By S. Rahighi, Fumiyo Ikeda, M. Kawasaki, M. Akutsu, N. Suzuki, R. Kato, Tobias Kensche, T. Uejima, S. Bloor, D. Komander and 3 more. Cell, 2009

767 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/05fc070d551cd8585ed119fdeafea4bd02906a9e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Ghosh
2. M. Hayden
3. Shizuo Akira
4. Taro Kawai
5. V. Dixit
6. Sharad Kumar
7. J. Tschopp
8. K. Newton

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. S. Ghosh
4. M. Hayden
5. V. Dixit
6. J. Tschopp
7. D. Komander
8. Sharad Kumar

In Molecular Biology

1. D. Komander
2. Shizuo Akira
3. J. Tschopp
4. V. Dixit
5. Taro Kawai
6. S. Ghosh
7. M. Hayden
8. Ivan Dikic

Citations in the corpus

• Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study (2020, background): “Indeed, lines of evidence have revealed the critical role of the non-canonical NF-κB pathway in TEC maturation and central-tolerance.351,352 Deficiency of noncanonical NF-κB inducers (RANK, LTα, LTβ, LIGHT, CD40, etc.), their receptors, and critical components of this pathway results in severe defec”
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “Head-to-tail linear polyubiquitination of NEMO by the linear ubiquitin-chain assembly complex (which consists of HOIL-1L and HOIP) has been shown to be an important process for IKK activatio”
• Ubiquitin-binding domains — from structures to functions (2009, background): “and are crucial for nuclear factor-κB (NF-κB) signallin”
• Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, unknown): “Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation.”
• NF-κB, the first quarter-century: remarkable progress and outstanding questions. (2012, background): “the active TNF/TNFR1 signaling complex (Haas 2009), and it was demonstrated that LUBAC was required for stabilization of the TNFR1 signaling complex and full activation of NF-kB by TNF and CD40 (Haas 2009; Rahighi et al. 2009; Tokunaga et al. 2009).”
• Breaking the chains: structure and function of the deubiquitinases (2009, background): “Linear ubiquitin chains, which are linked by peptide bonds, provide a precursor to ubiquitin but also have physiological roles in nuclear factor-κB (NF-κB) signallin”
• Post-translational modifications in signal integration (2010, background): “Recently, lysine-independent linkage of ubiquitin through the first methionine (termed a linear ubiquitin chain) has been described to be important for proper activation of NF-κB signaling following ligation of TNFα to its recepto”