Increased amygdala activation to angry and contemptuous faces in generalized social phobia.

By Murray B. Stein, Philippe R. Goldin, J. Sareen, L. E. Zorrilla, Gregory G. Brown. Archives of General Psychiatry, 2002

599 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/c131374f515b54c99e0caad38dc41650280d388f

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Citations in the corpus

Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. (2008, background): “Relative to the comparison group, GAD/MDD showed greater amygdala activation, xyz coordinates=25 −1 −18, t(18)=2.”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “…happy, and schematic angry facial expressions (Birbaumer et al, 1998; Blair et al, 2008b; Cooney et al, 2006; Evans et al, 2008; Gentili et al, 2008; Guyer et al, 2008; Phan et al, 2006b; Schneider et al, 1999; Stein et al, 2002b; Straube et al, 2004a, 2005; Veit et al, 2002; Yoon et al, 2007).”
Empathy versus personal distress: Recent evidence from social neuroscience. (2009, background): “Similarly, patients with generalized social phobia showed increased amygdala activation when exposed to angry or contemptuous faces (Stein et al., 2002).”
Selective aberrant functional connectivity of resting state networks in social anxiety disorder (2010, background): “Since neurobiological studies showed differences between SAD patients and HC during perceptive tasks as well as during public specking (e.g. Gentili et al., 2008; Lorberbaum et al., 2004; Stein et al., 2002), we also chose the VN, the AN, the SMN and the CEN.”
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (2007, background): “(2002) (11) 15 15 Negative and happy faces Negative-happy Yes fMRI”
Human Empathy Through the Lens of Social Neuroscience (2006, background): “Similarly, patients with generalized social phobia, which are characterized by fear of social interactions and sensitivity to disapproval by others, show increased amygdala activation when exposed to angry or contemptuous faces[87].”
A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. (2005, background): “However, individuals with social phobia appear to exhibit exaggerated amygdala responses to neutral faces alone,(59) as well as to contemptuous and angry faces vs happy faces.(58) Thus, whether exaggerated amygdala activation is demonstrated in a particular disorder may depend on the facial expressi”
A Developmental Examination of Amygdala Response to Facial Expressions (2008, background): “fMRI studies of face–emotion processing in adults and adolescents with affective disorders document dysfunctional neural circuitry involving amygdala regions, the ventral prefrontal cortex, and the anterior cingulate cortex (ACC) relative to psychiatrically healthy individuals (McClure et al., 2007;”
Discovering the neural basis of human social anxiety: a diagnostic and therapeutic imperative. (2004, background): “One noteworthy investigation reported preliminary evidence of amygdala hyperactivity in response to angry and contemptuous faces (11).”
Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder (2011, background): “…hyperactivation in response to aversive and potentially threatening social stimuli (Etkin andWager, 2007; Phelps et al., 2001; Rauch et al., 2003; Tillfors et al., 2001) and during face perception (Hariri et al., 2002; Phan et al., 2006; Stein et al., 2002) is consistently observed in SAD patients.”
The structural and functional connectivity of the amygdala: From normal emotion to pathological anxiety (2011, background): “Individuals with SAD reliably showed elevated amygdala reactivity when viewing " harsh " faces (facial expressions displaying anger, contempt, or a combination of both) [110–112], and even neutral faces [113], compared to healthy individuals in fMRI studies.”
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans (2005, background): “Because increased amygdala activation has been associated with social fear in social phobia (Stein et al., 2002), genetic risk for anxiety and depression (Pezawas et al., 2005), and possibly with social fear in autism A nominally significant reduction in valence in the SAM was not seen in the MDBF.”
Patterns of Emotional Reactivity and Regulation in Children with Anxiety Disorders (2010, background): “…individuals was recently demonstrated in functional magnetic resonance measures of blood oxygen level dependent responses in the amygdala (which is thought to be involved in threat detection) when anxious participants were shown threatening images (Phan et al. 2006; Stein et al. 2002, 2007).”
A susceptibility gene for affective disorders and the response of the human amygdala. (2005, background): “5-HTTLPR effects on behavior may be more closely related to such differential amygdala reactivity to affectspecific stimuli previously linked with behavioral variance and psychiatric illness.(37) Future attempts to explore the links between the 5-HTTLPR, amygdala reactivity, and dimensional measures”