The Neurocircuitry of Fear, Stress, and Anxiety Disorders

By Lisa M. Shin, Israel Liberzon. Neuropsychopharmacology, 2011

2,025 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/66638bd5df8e6ad2679744be6555a51e61ea6265

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Citations in the corpus

Understanding resilience (2013, background): “Other brain regions such as the dorsal anterior cingulate cortex and insular cortex have also been implicated in the maladaptive regulation of fear responses in PTSD, with some studies showing hyperresponsiveness and some showing hyporesponsiveness of these regions (Shin and Liberzon, 2010).”
Pain and Emotion: A Biopsychosocial Review of Recent Research (2011, positive): “Furthermore, reciprocal projections of the cortex to the subcortical defense circuit can either exacerbate or inhibit dysregulation, suggesting that conscious processes modulate fear, suffering, and disability (Shin & Liberzon, 2010).”
The Nature, Diagnosis, and Treatment of Neuroticism (2014, background): “…that hyperexcitability of limbic structures, along with limited inhibitory control by cortical structures, may be one explanation for the increased negative emotionality among individuals with such diagnoses (Etkin & Wager, 2007; Mayberg et al., 1999; Porto et al., 2009; Shin & Liberzon, 2010).”
When does proactivity have a cost? Motivation at work moderates the effects of proactive work behavior on employee job strain (2017, background): “Cortisol output indicates an activation of a hormone-based stress system, but activation of this system is not necessarily experienced subjectively as negative emotion (Shin & Liberzon, 2009).”
Optimizing Exposure Therapy for Anxiety Disorders: An Inhibitory Learning and Inhibitory Regulation Approach (2015, background): “…which is involved in processing contextual cues of conditioning, the insular cortex, which is involved in interoception and awareness of and sensitivity to visceral activity and the dorsal and rostral ACC, which appears to have a role in anticipation of the CS and US [Shin and Liberzon, 2010].”
Learned Helplessness at Fifty: Insights from Neuroscience (2016, background): “…to therapy, ventromedial prefrontal cortex dysregulation and impaired top-down inhibition of stress responsive limbic and brainstem structures have often been noted (e.g., DeRubeis, Siegle, & Hollon, 2008; Hartley & Phelps, 2010; Koenigs & Grafman, 2009; Rive et al., 2013; Shin & Liberzon, 2010).”
Posttraumatic Stress Disorder (2015, background): “Increased amygdala activation resulting from faulty modulatory input from the left ventromedial prefrontal cortex and, to a lesser extent, thehippocampus, underlies fear responses in PTSD.(42,43) The amygdala encodes the salience of aversive cues and integrates a reflex response mediated by effector”
Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect (2016, neutral): “…amygdala have been observed in a wide array of psychiatric disorders including: post-traumatic stress disorder, social phobias and specific phobias (Shin & Liberzon, 2010); unipolar and bipolar depression (Grotegerd, et al., 2014); drug addiction (Koob & Volkow, 2010); autism (Kleinhans, et al.,…”
Probing and regulating dysfunctional circuits using deep brain stimulation. (2013, positive): “This supports the notion that the clinical manifestations in patients with common neurological and psychiatric conditions, for example, Parkinson’s disease (PD), major depressive disorder (MDD), and Alzheimer’s disease (AD), reflect underlying dysregulation and malfunction in specific brain networks”
Consideration of the Psychological and Mental Health of the Elderly during COVID-19: A Theoretical Review (2020, background): “Fear is a natural defense mechanism against potentially threatening events that requires greater attention because, when chronic or imbalanced, it can become a key component of various mental disorders [28].”