Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.

By Amit Etkin, Tor D. Wager. American Journal of Psychiatry, 2007

3,257 citations recorded by the source corpus.

Subfields: Clinical Psychology, Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/5fe5a925c75d0bd81e8d6888952773b5f44663f5

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Citations in the corpus

Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Regions of the medial prefrontal cortex (mPFC), including the rostral anterior cingulate cortex, subgenual ACC (sgACC, Brodmann’s Area 25) and medial frontal gyrus, are all heavily connected to the amygdala and hippocampus, and critically involved in emotion regulation, attention bias, and fear exti”
Assessing Emotion Regulation in Social Anxiety Disorder: The Emotion Regulation Interview (2011, background): “This is a key limitation because emerging clinical research suggests that emotion dysregulation may underlie many mood and anxiety disorders (Kring and Werner 2004), including SAD (Etkin and Wager 2007; Turk et al. 2005).”
Anterior Insular Cortex and Emotional Awareness (2013, neutral): “*CORRESPONDENCE TO: Xiaosi Gu, PhD, Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London, United Kingdom WC1N 3BG. E-mail: xiaosi.gu@ucl.ac.uk”
Emotion Modulation in PTSD: Clinical and Neurobiological Evidence for a Dissociative Subtype (2010, background): “Patients with reexperiencing/hyperaroused PTSD exhibit abnormally low activation in medial anterior brain regions that are implicated in arousal modulation and emotion regulation more generally, including the ventromedial prefrontal cortex (19) and the rostral anterior cingulate cortex (24).”
The Role of Sleep in Emotional Brain Function (2014, background): “…of aversive events, increased anticipatory limbic activity positively predicts clinical features of anxiety disorders, such as worry and rumination (Etkin & Wager 2007, Nitschke et al 2009, Paulus & Stein 2006), many of which express co-occurring impairments in the quantity and quality of sleep…”
Emotion, Emotion Regulation, and Psychopathology (2014, background): “…fear response (or overexpression of emotion; Criterion E3/ E4), according to a meta-analysis, unlike other anxiety disorders (e.g., social anxiety disorder, specific phobia), PTSD is also associated with hypoactivation in brain structures associated with emotional experience (Etkin & Wager, 2007).”
UPDATED META‐ANALYSIS OF CLASSICAL FEAR CONDITIONING IN THE ANXIETY DISORDERS (2015, background): “Etkin A, Wager T. Functional neuroimaging of anxiety: a metaanalysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.”
Emotional Dysregulation and Negative Affect Mediate the Relationship Between Maternal History of Child Maltreatment and Maternal Child Abuse Potential (2014, background): “…with increased risk for a number of stress-related anxiety and mood disorders, and potentially accounting for co-morbidity among these disorders (Etkin and Wager 2007; Watson, O’Hara, and Stuart 2008; Wilamowska et al. 2010) are negative affect (i.e., feelings of distress, including sadness,…”
The Nature, Diagnosis, and Treatment of Neuroticism (2014, background): “…that hyperexcitability of limbic structures, along with limited inhibitory control by cortical structures, may be one explanation for the increased negative emotionality among individuals with such diagnoses (Etkin & Wager, 2007; Mayberg et al., 1999; Porto et al., 2009; Shin & Liberzon, 2010).”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “Consistent with the findings of the meta-analysis of Etkin and Wager (2007), relatively diminished rACC activation has been reported fairly consistently in PTSD, but not in other anxiety disorders.”
Prefrontal-subcortical pathways mediating successful emotion regulation. (2008, positive): “The amygdala is the affect-related region most commonly modulated during reappraisal (Ochsner and Gross, 2005, 2008); it has been implicated in detecting, attending to, and encoding into memory affectively arousing and especially threatening stimuli (Holland and Gallagher, 1999; Phelps, 2006; Whalen”
Understanding resilience (2013, background): “Patients with PTSD showed hyperactivation in the amygdala and hypoactivation in the ventromedial PFC and anterior hippocampus, which may indicate reduced top-down inhibition of the amygdala and account for exaggerated fear responses (Etkin and Wager, 2007).”
The influence of negative emotions on pain: Behavioral effects and neural mechanisms (2009, positive): “In accordance with these suggested functions, malfunctioning of the ACC has been reported for post-traumatic stress disorder (Liberzon and Martis, 2006), major depressive disorder and bipolar disorder (Drevets et al., 2008) as well as anxiety disorders (Etkin and Wager, 2007).”
The ecology of human fear: survival optimization and the nervous system (2015, background): “…amygdala activation to fearful faces has also been observed in individuals scoring high on measures of trait anxiety (Ewbank et al., 2009), patients with generalized anxiety disorder (Etkin et al., 2004; Etkin and Wager, 2007) and soldiers suffering from combat stress (vanWingen et al., 2011).”