Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans

By Peter Kirsch, C. Esslinger, Qiang Chen, D. Mier, S. Lis, Sarina Siddhanti, H. Gruppe, Venkata S. Mattay, B. Gallhofer, Andreas Meyer-Lindenberg. Journal of Neuroscience, 2005

1,560 citations recorded by the source corpus.

Subfields: Experimental and Cognitive Psychology, Genetics, Social Psychology

View Paper: https://www.semanticscholar.org/paper/f90cdb5a0044fae9ed49386930e5c4f7c7615994

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Experimental and Cognitive Psychology

1. Alan G. Sanfey
2. James K. Rilling
3. G. Domes
4. Andreas Meyer-Lindenberg
5. Colin F. Camerer
6. M. Heinrichs
7. Ernst Fehr
8. L. Young

In Genetics

1. Andreas Meyer-Lindenberg
2. Daniel R. Weinberger
3. Ernst Fehr
4. L. Young
5. M. Flinn
6. D. Narvaez
7. Paul J. Zak

In Social Psychology

1. Angelika Dimoka
2. M. Heinrichs
3. Alan G. Sanfey
4. G. Domes
5. Ernst Fehr
6. L. Young
7. James K. Rilling
8. Heather E. Ross

Citations in the corpus

• Neuropeptidergic regulation of affiliative behavior and social bonding in animals. (2006, background): “A complementary fMRI study showed that intranasal oxytocin administration reduced amygdalar activation, effectively uncoupling the amygdala from downstream brainstem targets of fear and anxiety (Kirsch et al., 2005).”
• What Does the Brain Tell Us About Trust and Distrust? Evidence from a Functional Neuroimaging Study (2010, background): “Oxytocin also dampens activity in the amygdala (Kirsch et al. 2005), thus reducing the impact of betrayal (similar to distrust).”
• Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans (2010, background): “The social recognition memory-enhancing effects in humans (Guastella et al., 2008b; Savaskan et al., 2008; Rimmele et al., 2009) and other animals (Ferguson et al., 2001) as well as the anxiolytic effects of OT (Kirsch et al., 2005) appear to involve the amygdala.”
• Evolution and ontogeny of stress response to social challenges in the human child (2006, background): “Synergistically, oxytocin has important eVects on social cognition and fear (Kirsch et al., 2005).”
• The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences. (2013, background): “, 2007) and decreased functional coupling between the amygdala and brainstem (Kirsch et al., 2005) in healthy males in response to negative emotional stimuli.”
• Social neuroeconomics: the neural circuitry of social preferences. (2007, result): “The hypot hesis that the fearof-betrayal-reducing effect of oxytocin might be due to a reduced activation of the amygdala is consistent with a study [48] showing that OT dampens amygdala activity and its connections to the brainstem if subjects view emotionally arousi ng p ctures.”
• Informal Caregiving: A Reappraisal of Effects on Caregivers (2014, neutral): “For example, oxytocin appears to downregulate HPA (hypothalamic-pituitaryadrenal) axis activity (Carter, 1998), decrease blood-pressure, (Petersson, Alster, Lundeberg, & Uvnas Moberg, 1996), reduce activation of the amygdala and its functional connectivity to the brainstem (Kirsch et al., 2005), and”
• The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior (2010, neutral): “(Kirsch et al., 2005) The presence or role of V1a receptors in the human amygdala remains to be defined.”