A susceptibility gene for affective disorders and the response of the human amygdala.

By Ahmad R. Hariri, Emily M. Drabant, Karen E. Muñoz, Bhaskar S. Kolachana, Venkata S. Mattay, Michael Egan, Daniel R. Weinberger. Archives of General Psychiatry, 2005

845 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/37b370f8b09d7643a029b6548e1bccf0b070fac6

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Affective Neuroscience: Past, Present, and Future (2009, background): “There is emerging but controversial evidence that activation to fearful faces is greater in individuals possessing particular genetic attributes, for example individuals characterized by the short allele variant in the human serotonin transporter gene (SLC6A4) (Hariri et al., 2005).”
Temperament theory and the study of cognition-emotion interactions across development (2007, background): “Individual differences in amygdala activation also have been proposed as mediators of the association between serotonin transporter genes and individual differences in reactivity to stress and negative life events (Caspi et al., 2002; Fox et al., 2005; Hariri et al., 2002, 2005).”
Two Genes Predict Voter Turnout (2008, background): “Furthermore, a number of studies show that the amygdala becomes ‘‘hypersensitive’’ during the presentation of aversive or threatening social stimuli in individuals with either the short 5HTT allele (Bertolino et al. 2005; Hariri et al. 2002; Hariri et al. 2005; Heinz et al. 2005) or the low MAOA a”
The evolutionary genetics of personality (2007, background): “In the exemplary case of neuroticism, amygdala reactivity (Hariri et al., 2002, 2005) provides an especially good example of a mediating endophenotype, though there are likely several others.”
The Role of Early Life Stress as a Predictor for Alcohol and Drug Dependence (2010, background): “The variant low-activity short “S” allele is associated with an attenuated response to dexamethasone (Glatz et al. 2003), greater amygdala activity in response to fearful stimuli (Hariri et al. 2005), and impaired feedback circuitry for the extinction of negative affect (Pezawas et al. 2005).”
Coping resources, coping processes, and mental health. (2007, methodology): “For example, Hariri et al. (2005) used fMRI to examine the relation of www.annualreviews.org • Coping 389 the 5-HTTLPR to amygdala responses to threat-relevant stimuli.”
The experience of emotion. (2007, background): “…of psychopathologies characterized by affective disturbances, including depression (e.g., Anand et al. 2005, Drevets 2000, Drevets et al. 1997, Hariri et al. 2005, Lacerda et al. 2004, Mayberg 1997, Pezawas et al. 2005), schizophrenia (e.g., Fahim et al. 2005a,b), obsessive-compulsive…”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, background): “…two copies of the s allele also exhibit traits of anxiety (Lesch et al., 1996), increased risk to develop depression after tryptophan depletion (Neumeister et al., 2002), and increased amygdala responses to frightening faces (Hariri et al., 2002, 2005; Pezawas et al., 2005; Munafò et al., 2007).”
Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory (2011, background): “…in the filtering of incoming sensory information, including the temporal cortex (Boutros et al., 1995), prefrontal cortex (Shimamura, 2000), amygdala (Hariri et al., 2005), and thalamus (McCormick & Bal, 1994), and such filtering might arguably act as a neural substrate of context sensitivity.”