Mammalian mirtron genes.

By Eugene Berezikov, W. Chung, Jason Willis, Edwin Cuppen, Eric C. Lai. Molecules and Cells, 2007

875 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/060fc31ceafc8c7ce8b61ba0e4676f461ab7ad51

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Citations in the corpus

Small RNA sorting: matchmaking for Argonautes (2010, background): “For example, mirtrons have been found in flies and mammal”
Biogenesis of small RNAs in animals (2009, background): “Apart from canonical intronic miRNAs, small groups of miRNA-like RNAs have been discovered in introns in flies and mammal”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “mirtron transfer to the cytoplasm in some species including Xenopus laevis oocytes and Drosophila but it remains unclear whether this occurs in mammals [97, 102, 106].”
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions (2016, background): “A subclass of miRNAs, called mirtrons, bypass the initial Drosha cleavage and instead depend on splicing and debranching to produce the pre-miRNA molecules which are the substrates for Dicer mediated miRNA maturation [11,12].”
MicroRNAs in development and disease. (2011, background): “Alternatively, a few intronic pri-miRNAs (mirtrons) bypass Drosha/DGCR8 and are processed by the splicing machinery (34, 516).”
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. (2010, background): “…included massively parallel signature sequencing (MPSS) (Mineno et al. 2006), miRNA serial analysis of gene expression (miRAGE) (Cummins et al. 2006), 454 pyrosequencing (Berezikov et al. 2006a, 2007; Calabrese et al. 2007), and Illumina sequencing (Babiarz et al. 2008; Kuchenbauer et al. 2008).”
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, methodology): “Dicer knockout cells were produced by first deriving ES cells (Blelloch et al. 2006) from Dicer flox/flox mice (Harfe et al. 2005).”
MicroRNAs in human cancer. (2013, background): “DGCR8 and RNASEN independent miRNAs include mirtrons and tailed mirtrons, which release their pre-miRNA by splicing and exonuclase trimming [80, 81].”
Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “Mirtrons, for example, appear to be microRNAs in which pre-mRNA intron splicing substitutes for Drosha processing of pri-miRNAs (Berezikov et al. 2007).”
The Genetic Signatures of Noncoding RNAs (2009, background): “At least some of these RNAs, including intronic RNAs, are precursors for small regulatory RNAs like microRNAs (miRNAs), small interfering RNAs (siRNAs), piwi-interacting RNAs (piRNAs), and small nucleolar RNAs (snoRNAs) [58–68].”