The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

By Qihong Huang, Kiranmai Gumireddy, Mariette Schrier, C. Sage, Remco Nagel, S. Nair, D. Egan, Anping Li, Guanghua Huang, Andres J Klein-Szanto and 6 more. Nature Cell Biology, 2008

1,014 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b703d6e13dd8dcd166db7b130bbf0b49c0964f52

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Citations in the corpus

MicroRNA control in the immune system: basic principles. (2009, background): “…to various aspects of this Cell 136, January 9, 2009 ©2009 Elsevier Inc. 33 process, including tumor metastasis and cancer stem cell maintenance (Huang et al., 2008; Kent and Mendell, 2006; Ma et al., 2007; Tavazoie et al., 2008; Yu et al., 2007). miRNAs appear also to be heavily involved in…”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “In a recent study, miR-373 and miR-520c were shown to stimulate cancer cell migration and invasion with no effects on cell proliferation in MCF-7 cells [79].”
MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “miR-373 was previously identified by Agami's group as a potential oncogene in testicular germ cell tumours owing to its ability to overcome HRAS-induced p53 responses and to participate in cell transformatio”
Lost in translation: an assessment and perspective for computational microRNA target identification (2009, background): “Each miRNA is 19–24 nucleotides in length and is processed from a longer transcript, referred to as the primary transcript (pri-miRNA), which can be up to thousands of nucleotides long.”
Epithelial-mesenchymal transitions in development and disease. (2009, background): “In addition to the members of the miR200 family, miR-10b, miR-373, and miR-520c have also been implicated in the progression of breast carcinoma (Huang et al., 2008; Ma et al., 2007), and miR-21 is upregulated during TGFβ-induced EMT in tumor cell lines (Zavadil et al.”
miR2Disease: a manually curated database for microRNA deregulation in human disease (2008, background): “(40) found that significant upregulation of miR-373 and miR-520c stimulates breast cancer cell migration and invasion by the suppression of CD44.”
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis (2010, background): “Subsequently, several other miRNAs have been identified as either promoters or suppressors of metastasi”
Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, background): “373* Involvement in tumor migration and invasion present in exosomes [39,46]”
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy (2011, neutral): “Additional miRNAs that are involved in metastasis (in particular in breast cancer) include miR-373, miR-520c, miR-126 and miR-335 (Ref”
MicroRNAs in development and disease. (2011, background): “In addition to miR10b, upregulation of miR-373 and miR-520c also specifically promote metastasis (250).”
A microRNA DNA methylation signature for human cancer metastasis (2008, background): “Recently, a new function mediating tumor metastasis in breast cancer has been assigned to miRNAs, by which this malignant step is promoted (7, 8) or suppressed (9).”