miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

By Christine Esau, Scott Davis, S. Murray, Xing Yu, S. Pandey, Michael Pear, L. Watts, Sheri L. Booten, M. Graham, R. Mckay and 7 more. Cell Metabolism, 2006

2,125 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/833c76908226a034c4628c9ea24d019b4a7b6827

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Citations in the corpus

Development of microRNA therapeutics is coming of age (2014, positive): “…to man and implicated in the regulation of hepatic cholesterol, lipid and iron metabolism and in maintaining liver cell identity (Lagos-Quintana et al , 2002; Kru¨tzfeldt et al , 2005; Wienholds et al , 2005; Esau et al , 2006; Elme´n et al , 2008a,b; Castoldi et al , 2011; Jopling, 2012).”
An overview of microRNAs (2015, background): “This effect was also observed in mouse and primate studies whereby miR-122 was inhibited by an antisense oligonucleotide[182, 183].”
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, background): “Often, miRNAs can reduce the level of target transcripts (32, 33).”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “O - methoxyethyl groups resulted in lower plasma cholesterol (Esau et al, 2006).”
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. (2012, positive): “Thus, our data suggest that the pathway disturbances associated with Mir122a deletion contribute to tumor initiation and progression. our study differs from those using either in vivo knockdown of Mir122a (5, 6, 8, 38) or Dicer1 (17, 18).”
Silencing of microRNA families by seed-targeting tiny LNAs (2011, background): “Additionally, phosphorothioate backbone modifications provide high biostability and facilitate delivery of antimiRs to the live”
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. (2011, background): “, wherein it is responsible for the maintenance of fatty acid metabolis”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “370 Cancer Metastasis Rev (2009) 28:369–378 homeostasis in the liver [ 20 ].”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “, or in which miRNA levels were experimentally altere”
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. (2012, positive): “Both KO and LKO mice develop normally and are viable and, consistent with studies performed using antisense-mediated miR-122 inhibition, exhibit reduced serum cholesterol (2, 3, 11).”