Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.

By Yong Zhao, J. Ransom, Ankang Li, V. Vedantham, Morgan von Drehle, Alecia N. Muth, Takatoshi Tsuchihashi, Michael T. McManus, R. Schwartz, Deepak Srivastava. Cell, 2007

1,515 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c507d7174aa01a97c565693f52c0ed45f12b1377

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Citations in the corpus

RNA silencing: Methods and protocols (2006, positive): “These mutations cause profound cardiac defects and lead to either embryonic or neonatal death.[17-19] Other studies reported that the hearts of these knock-out mice developed hypertrophy, fibrosis, and ventricular dilatation, resulting in HF.”
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure (2008, background): “5-Cre, led to defects in heart development and embryonic lethality (10).”
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. (2008, positive): “…differentiation: serum response factor (SRF), MyoD, and Mef2 (Zhao et al., 2005; Kwon et al., 2005; Sokol and Ambros, 2005; Rao et al., 2006). miR-1 promotes differentiation of cardiac progenitors and exit from the cell cycle in mammals and in flies (Zhao et al., 2005, 2007; Kwon et al., 2005).”
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. (2008, positive): “MicroRNAs could act either by regulating a specific set of critical developmental genes or by reinforcing gene-expression programs through suppression of transcriptional noise (Bartel and Chen, 2004; Hornstein and Shomron, 2006; Yekta et al., 2004 ).”
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. (2007, methodology): “We followed up on this possibility using predicted local secondary structure with published rubrics to score site accessibility (Robins et al., 2005; Zhao et al., 2005, 2007; Long et al., 2007).”
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis (2011, background): “It has been reported that the selective disruption of the miR-1–2 locus in mice results in a severe cardiac phenotype, including 50% embryonic lethality with frequent ventricular septum defect”
TransmiR: a transcription factor–microRNA regulation database (2009, background): “miRNAs play critical roles in many essential biological processes, such as proliferation (4,5), metabolism (6,7), differentiation (8), development (9,10), apoptosis (7,11,12) and cellular signaling (13).”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Thus, the cardiacspecific deletion of Dicer results in defective heart development and embryonic lethality.(22) Moreover, the postnatal cardiac-specific knockout of Dicer leads to dilated cardiomyopathy associated with heart failure(23) supporting the role of Dicer for cardiac development and functi”
Altered microRNA expression in human heart disease. (2007, background): “Out of 475 currently described human miRNAs (9), three (miR-1, miR-133, and miR-208) are highly enriched in the heart (3, 11) and are important regulators of heart development and myocyte differentiation (5, 20, 23, 24).”
MicroRNAs in human cancer. (2013, background): “In mammalian cells under steady state conditions, miRNAs have been shown to destabilize targeted transcripts [108–111] through a variety of mechanisms, including de-capping and deadenylation; target mRNA and protein abundance changes track closely [108, 109, 112, 113].”
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. (2009, background): “The global role of miRNA function in the heart has been addressed by conditionally inhibiting miRNA maturation in the murine heart and has revealed that miRNAs play an essential role during development (13, 14).”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “The functional relevance of one class of ncRNAs in particular, microRNAs (miRNAs), has received much attention, with important roles in a myriad of cellular processes including muscle differentiation and cardiac development 4,5 , as well as neural stem cell differentiation and neurogenesis 6,7 .”