New functions for the matrix metalloproteinases in cancer progression

By M. Egeblad, Zena Werb. Nature Reviews. Cancer, 2002

6,189 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/be753f72425fce2c10539a76f164b0b289bc6d55

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Citations in the corpus

Gene expression profiling of the tumor microenvironment during breast cancer progression (2009, background): “MMP14, a membrane-type matrix metalloprotease, can activate MMP2 protease activity, which degrades type IV collagen, the major structural component of the basement membrane [40,41].”
Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “Cleavage of type I collagen by MMP1, -8, -13 and -14 (MT1-MMP) results in generation of characteristic fragments that are 3/4 and 1/4 of the length of the native molecule ([56,57], Figure 1A).”
Matrix MetalloProteinases (MMPs) andTissue Inhibitors of MetalloProteinases (TIMPs): positive and negative regulators intumor cell adhesion (2010, neutral): “MMPs promote carcinogenesis and this has been demonstrated in a number of genetically modified animal models [57].”
Matrix-degrading Metalloproteinases in Photoaging (2009, positive): “E-mail: dianemch@umich.edu 2Authors contributed equally to this manuscript Abbreviations: ECM, extracellular matrix; MMP, matrix metalloproteinase; RT-PCR, reverse transcriptase PCR members, 24 of which are expressed in mammals (Sternlicht and Werb, 2001; Egeblad and Werb, 2002; Fu et al., 2008).”
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. (2002, neutral): “To determine whether any factors linked to VEGFR-1 might have an effect on the (Stetler-Stevenson, 1999; Egeblad and Werb, 2002).”
Modelling glandular epithelial cancers in three-dimensional cultures (2005, background): “MMPs have a well-established role in invasion and metastasi”
Matrix metalloproteinases. (2010, background): “7) than that derived from their direct degradative action on extracellular matrix components [15,131,132].”
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases (2007, background): “They play a role in many physiological processes, such as embryo implantation, bone remodelling and organogenesis, and have additional roles in the reorganization of tissues during pathological conditions such as inflammation, wound healing and invasion of cancer cell”
Systemic spread is an early step in breast cancer. (2008, background): “This array comprised 41 cDNAs encoding matrix-metalloproteases (MMPs) and cathepsins that have earlier been implied in invasion and metastasis ( Egeblad and Werb, 2002; Turk et al., 2002).”
Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “In most other cases, however, tissue remodeling is much less discernible with spatially restricted cleavage, deposition, or rearrangement of its components (Egeblad and Werb 2002).”