Modelling glandular epithelial cancers in three-dimensional cultures

By Jayanta Debnath, J. Brugge. Nature Reviews. Cancer, 2005

1,090 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/8df67f79ed2fcc0eddc42863554f8f12dbf29342

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Citations in the corpus

An Integrated Mechanistic Model of Pan-Cancer Driver Pathways Predicts Stochastic Proliferation and Death (2017, background): “We focus on a widely-studied non-transformed cell line, MCF10A (Debnath and Brugge, 2005) to leverage literature data and establish a baseline for “normal” cell behavior before describing transformed contexts with genetic instability and multiple poorly understood mutations.”
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “could be more relevant to the in vivo situation than the complete EMT [180].”
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. (2007, positive): “The three-dimensional (3D) Madin-Darby canine kidney (MDCK) cell system is an excellent model of epithelial morphogenesis in vitro (Debnath and Brugge, 2005; Lubarsky and Krasnow, 2003; O’Brien et al., C 2002).”
Complex networks orchestrate epithelial–mesenchymal transitions (2006, background): “Better in vitro models are clearly required to study EMT, and those obtained in three-dimensional cultures where epithelial cells can polarize and form functional glandular structures hold particular promis”
MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “When embedded in a collagen matrix, normal epithelial cells proliferate and assemble into spheroids, which feature a centrally localized, hollow lumen, surrounded by polarized cell”
Modeling tissue morphogenesis and cancer in 3D. (2007, positive): “The mechanisms of aberrant proliferation and invasion in cancer have been analyzed fruitfully in 3D model systems (Bissell and Labarge, 2005; Debnath and Brugge, 2005; Kim, 2005).”
Three-Dimensional Cell Culture Matrices: State of the Art (2008, background): “Here, the aim is to facilitate systematic analysis of cell biology at the molecular level that will significantly improve the understanding of tissue physiology and pathophysiology.(19,20) For experiments within this application, the 3D matrix should be designed to mimic the 3D organization and the ”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “The changed morphology of the cells can affect their function [16, 17], the organization of the structures inside the cell, secretion and cell signalling [18, 19].”
An integrated computational/experimental model of tumor invasion. (2006, background): “This mechanism may help to explain the morphology of an aggressive genotype recently observed for breast cancer in vitro with transformed mammary epithelial cells (52), where excess”