Systemic spread is an early step in breast cancer.

By Yves Hüsemann, J. Geigl, Falk Schubert, P. Musiani, M. Meyer, E. Burghart, G. Forni, R. Eils, T. Fehm, G. Riethmüller and 1 more. Cancer Cell, 2008

1,221 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/08f4d778697a23598e585d042dfebd44ad76b5f6

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In Biomedical Engineering

1. K. Polyak
2. J. P. Thiery
3. Mehmet Toner
4. A. Marusyk
5. R. Weinberg
6. J. Massagué
7. D. Nguyen

In Cancer Research

1. R. Weinberg
2. J. Massagué
3. K. Pantel
4. D. Pattabiraman
5. C. Alix‐Panabières
6. Arthur W. Lambert
7. M. Nieto
8. J. P. Thiery

In Oncology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. J. Massagué
5. D. Pattabiraman
6. J. P. Thiery
7. Arthur W. Lambert
8. J. Tsai

Citations in the corpus

• Epithelial-mesenchymal transitions in development and disease. (2009, background): “Interestingly, systemic spread has been detected from early lesions in HER-2 transgenic mice and in human ductal carcinoma suggesting that metastasis is not necessarily a late event in tumor progression (Hüsemann et al., 2008).”
• Early dissemination seeds metastasis in breast cancer (2016, neutral): “From weeks 4–9 we observed micro-invasion 8 , and a sharp decline in the ratio of DCCs to total tumour area (a measure of cell numbers at risk to disseminate) during primary tumour growth (Extended Data Fig 1a).”
• Latent bone metastasis in breast cancer tied to Src-dependent survival signals (2009, background): “Breast tumors are competent for early dissemination and infiltration of distant organs (Husemann et al., 2008; Stoecklein et al., 2008) but, unlike other types of tumors (e.g., lung adenocarcinoma, pancreatic carcinoma), the disseminated breast cancer cells often lack the competence for immediate…”
• Circulating tumor cells: approaches to isolation and characterization (2011, positive): “In a mouse model of breast cancer, disseminated tumor cells (DTCs) in the bone marrow can be detected in the premalignant phases of breast cancer, suggesting an early spread to distant organs (Hüsemann et al., 2008).”
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “Breast tumors, for example, undergo dissemination from an early stage (Husemann et al., 2008; Klein et al., 1999), but metastasis to bones, lungs, brain, or liver may not manifest until years or decades after the diagnosis and removal of the primary tumor (Karrison et al., 1999; Schmidt-Kittler et…”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “More recent reports, however, suggest that dissemination can often occur early during the process of neoplastic transformation, perhaps even before departing cells are fully transformed (Husemann et al., 2008; Podsypanina et al., 2008; Rhim et al., 2012).”
• Tumor self-seeding by circulating cancer cells (2009, background): “Shedding of tumor cells into the circulation may occur in large numbers and from early stages of tumor formation (Husemann et al., 2008; Pantel and Brakenhoff, 2004; Stoecklein et al., 2008).”
• EMT and dissemination precede pancreatic tumor formation (2012, background): “Although direct evidence for this model is limited, recent studies of breast cancer are consistent with the notion that metastatic seeding may be mediated by cells that would not meet a standard definition of cancer (Hüsemann et al., 2008; Podsypanina et al., 2008).”
• Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells (2013, background): “disseminated before the tumor is diagnosed, as in pancreatic and breast carcinomas (82, 83).”