Matrix metalloproteinases.

By O. Zítka, J. Kukacka, S. Krizkova, D. Húska, V. Adam, M. Masařík, R. Průša, R. Kizek. Current Medicinal Chemistry, 2010

2,426 citations recorded by the source corpus.

Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.

Subfields: Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/a60c24fc5badd989c638432337adb839e6a95484

Citations in the corpus

• Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. (2009, neutral): “MMP2 is an important protein in the degradation of various extracellular matrix molecules, including collagen type I, IV, V, VII, X, and XI, as well as elastin, gelatins, laminin, aggrecan, and vitronectin (87).”
• The blood-brain barrier in Alzheimer's disease (2017, neutral): “Interestingly, neutrophils, which have recently been shown tomigrate in the AD brain, contain preformedMMP-9 proteins in their granules, which can be released during transendothelial migration, leading to basement membrane damage (Opdenakker et al., 2001; Noble et al., 2002; Zenaro et al., 2015).”
• TGF-beta and fibrosis in different organs - molecular pathway imprints. (2009, neutral): “tissue inhibitors [127] suppresses the degrading pathways.”
• The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “MMPs, in line with early reports showing that intracerebral injection of MMPs increased brain capillary permeability [104].”