Matrix-degrading Metalloproteinases in Photoaging
By T. Quan, Zhaoping Qin, W. Xia, Y. Shao, J. Voorhees, G. Fisher. Journal of Investigative Dermatology Symposium Proceedings, 2009
672 citations recorded by the source corpus.
Ultraviolet (UV) irradiation from the sun adversely impacts skin health through complex, multiple molecular pathways. Premature skin aging (photoaging) is among the most widely appreciated harmful effects of chronic exposure to solar UV irradiation. Extensive damage to the dermal connective tissue is a hallmark of photoaged skin. Disruption of the normal architecture of skin connective tissue impairs skin function and causes it to look aged. UV irradiation induces expression of certain members of the matrix metalloproteinase (MMP) family, which degrade collagen and other extracellular matrix (ECM) proteins that comprise the dermal connective tissue. Although the critical role of MMPs in photoaging process is undeniable, important questions remain. This article summarizes our current understanding regarding the role of MMPs in the photoaging process and presents new data that 1) describe expression and regulation by UV irradiation of all members of the MMP family in human skin in vivo, and 2) quantify the relative contributions of the epidermis and dermis to expression of UV irradiation-induced MMPs in human skin in vivo.
Subfields: Biomaterials, Cancer Research, Dermatology
View Paper: https://www.semanticscholar.org/paper/78a1752a6733b7c7ffaa716e9b38f67dd7920a8a
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- J. Shin
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- M. Komine
Citations in the corpus
- Molecular Mechanisms of Dermal Aging and Antiaging Approaches (2019, background): “In aged skin, the production of collagen decreases and its degradation increases, which leads to an overall reduction in collagen amount [3,9,10].”
- Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis (2016, background): “To date, at least 28 different types of MMPs have been identified that play important roles in various pathophysiological processes including photoaging, wound healing, skeletal growth and remodeling, arthritis, inflammation, angiogenesis, and cancer [3,8,9].”